Nonclassical GH insensitivity: Characterization of mild abnormalities of GH action

Helen L. Storr, Sumana Chatterjee, Louise A. Metherell, Corinne Foley, Ron G. Rosenfeld, Philippe F. Backeljauw, Andrew Dauber, Martin O. Savage, Vivian Hwa

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


GH insensitivity (GHI) presents in childhood with growth failure and in its severe form is associated with extreme short stature and dysmorphic and metabolic abnormalities. In recent years, the clinical, biochemical, and genetic characteristics of GHI and other overlapping short stature syndromes have rapidly expanded. This can be attributed to advancing genetic techniques and a greater awareness of this group of disorders. We review this important spectrum of defects, which present with phenotypes at the milder end of the GHI continuum. We discuss their clinical, biochemical, and genetic characteristics. The objective of this review is to clarify the definition, identification, and investigation of this clinically relevant group of growth defects. We also review the therapeutic challenges of mild GHI.

Original languageEnglish (US)
Pages (from-to)476-505
Number of pages30
JournalEndocrine reviews
Issue number2
StatePublished - 2019

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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