Noncovalent functionalization of mesoporous silica nanoparticles with amphiphilic peptides

Melis Sardan, Adem Yildirim, Didem Mumcuoglu, Ayse B. Tekinay, Mustafa O. Guler

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The surface of mesoporous silica nanoparticles (MSNs) has been modified for enhancing their cellular uptake, cell targeting, bioimaging, and controlled drug release. For this purpose, covalent anchorage on the silica surface was predominantly exploited with a wide range of bioactive molecules. Here, we describe a facile self-assembly method to prepare a hybrid peptide silica system composed of octyl-modified mesoporous silica nanoparticles (MSNs) and peptide amphiphiles (PAs). The hydrophobic organosilane surface of mesoporous silica was coated with amphiphilic peptide molecules. The peptide functionalized particles exhibited good cyto-compatibility with vascular smooth muscle and vascular endothelial cells. The peptide coating also improved the cellular uptake of particles up to 6.3 fold, which is promising for the development of highly efficient MSN based theranostic agents.

Original languageEnglish (US)
Pages (from-to)2168-2174
Number of pages7
JournalJournal of Materials Chemistry B
Issue number15
StatePublished - Apr 21 2014
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry
  • Biomedical Engineering
  • General Materials Science


Dive into the research topics of 'Noncovalent functionalization of mesoporous silica nanoparticles with amphiphilic peptides'. Together they form a unique fingerprint.

Cite this