TY - JOUR
T1 - Nonhuman primate models of human viral infections
AU - Estes, Jacob D.
AU - Wong, Scott W.
AU - Brenchley, Jason M.
N1 - Publisher Copyright:
© 2018 Macmillan Publishers Ltd., part of Springer Nature.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Humans have a close phylogenetic relationship with nonhuman primates (NHPs) and share many physiological parallels, such as highly similar immune systems, with them. Importantly, NHPs can be infected with many human or related simian viruses. In many cases, viruses replicate in the same cell types as in humans, and infections are often associated with the same pathologies. In addition, many reagents that are used to study the human immune response cross-react with NHP molecules. As such, NHPs are often used as models to study viral vaccine efficacy and antiviral therapeutic safety and efficacy and to understand aspects of viral pathogenesis. With several emerging viral infections becoming epidemic, NHPs are proving to be a very beneficial benchmark for investigating human viral infections.
AB - Humans have a close phylogenetic relationship with nonhuman primates (NHPs) and share many physiological parallels, such as highly similar immune systems, with them. Importantly, NHPs can be infected with many human or related simian viruses. In many cases, viruses replicate in the same cell types as in humans, and infections are often associated with the same pathologies. In addition, many reagents that are used to study the human immune response cross-react with NHP molecules. As such, NHPs are often used as models to study viral vaccine efficacy and antiviral therapeutic safety and efficacy and to understand aspects of viral pathogenesis. With several emerging viral infections becoming epidemic, NHPs are proving to be a very beneficial benchmark for investigating human viral infections.
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U2 - 10.1038/s41577-018-0005-7
DO - 10.1038/s41577-018-0005-7
M3 - Review article
C2 - 29556017
AN - SCOPUS:85044223320
SN - 1474-1733
VL - 18
SP - 390
EP - 404
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 6
ER -