@article{8a0b5680e64240449170ba7bc68ca0fc,
title = "Noninvasive blood tests for fetal development predict gestational age and preterm delivery",
abstract = "Noninvasive blood tests that provide information about fetal development and gestational age could potentially improve prenatal care. Ultrasound, the current gold standard, is not always affordable in low-resource settings and does not predict spontaneous preterm birth, a leading cause of infant death. In a pilot study of 31 healthy pregnant women, we found that measurement of nine cell-free RNA (cfRNA) transcripts in maternal blood predicted gestational age with comparable accuracy to ultrasound but at substantially lower cost. In a related study of 38 women (25 full-term and 13 preterm deliveries), all at elevated risk of delivering preterm, we identified seven cfRNA transcripts that accurately classified women who delivered preterm up to 2 months in advance of labor. These tests hold promise for prenatal care in both the developed and developing worlds, although they require validation in larger, blinded clinical trials.",
author = "Ngo, {Thuy T.M.} and Moufarrej, {Mira N.} and Rasmussen, {Marie Louise H.} and Joan Camunas-Soler and Wenying Pan and Jennifer Okamoto and Neff, {Norma F.} and Keli Liu and Wong, {Ronald J.} and Katheryne Downes and Robert Tibshirani and Shaw, {Gary M.} and Line Skotte and Stevenson, {David K.} and Biggio, {Joseph R.} and Elovitz, {Michal A.} and Mads Melbye and Quake, {Stephen R.}",
note = "Funding Information: Supported by the Bill and Melinda Gates Foundation, the March of Dimes Prematurity Research Center at Stanford University, the March of Dimes Prematurity Initiative Grant at the University of Pennsylvania, and the Chan Zuckerberg Biohub. This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit http://creativecommons. org/licenses/by/4.0/. This license does not apply to figures/ photos/artwork or other content included in the article that is credited to a third party; obtain authorization from the rights holder before using such material. Publisher Copyright: {\textcopyright} 2017 The Authors.",
year = "2018",
month = jun,
day = "8",
doi = "10.1126/science.aar3819",
language = "English (US)",
volume = "360",
pages = "1133--1136",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6393",
}