Nonmammalian model systems of zebrafish

B. Appel, K. Monk

Research output: Chapter in Book/Report/Conference proceedingChapter


Glial cells in developing organisms are highly dynamic, often engaging in long-distance migration and specific cell interactions such as axon ensheathment. Such behaviors are difficult to observe directly using rodent and bird models; consequently, our knowledge of mechanisms that guide glial development remains incomplete. Zebrafish have emerged as a strong model system for glial cell investigations; their small size, optical clarity, and rapid development permit direct observation through time-lapse imaging. Furthermore, forward genetic screens for mutations that disrupt glial development can be carried out at relatively low cost, thereby helping to define genes with essential glial functions.

Original languageEnglish (US)
Title of host publicationPatterning and Cell Type Specification in the Developing CNS and PNS
Subtitle of host publicationComprehensive Developmental Neuroscience, Second Edition
Number of pages18
ISBN (Electronic)9780128144053
ISBN (Print)9780128144060
StatePublished - Jan 1 2020


  • Astrocyte
  • Mutation
  • Myelin
  • Neural precursor
  • Neural stem cell
  • Oligodendrocyte
  • Radial glia
  • Schwann cell
  • Time-lapse imaging
  • Transgenic
  • Zebrafish

ASJC Scopus subject areas

  • Neuroscience(all)


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