TY - JOUR
T1 - NON‐RANDOM RELATIONSHIPS AMONG AMINO ACIDS IN PROTEIN SEQUENCES
AU - Black, John A.
AU - Harkins, Richard N.
AU - Stenzel, Peter
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1976/3
Y1 - 1976/3
N2 - We have computed the observed distribution of amino acid pairs n, n + 1 up to n, n + 10 within 100 unrelated protein sequences containing a total of 14,034 amino acids. The expected distribution of the same amino acid pairs was calculated assuming that the amino acids within each sequence are arranged in random order. Statistical analysis of the data shows that amino acids in the n, n + 1 and n, n + 3 relationship deviate from random expectation at the 1% level of significance. These relationships are consistent with known secondary structures; however, there are no amino acid pairs which obviously contribute to the non‐random result.
AB - We have computed the observed distribution of amino acid pairs n, n + 1 up to n, n + 10 within 100 unrelated protein sequences containing a total of 14,034 amino acids. The expected distribution of the same amino acid pairs was calculated assuming that the amino acids within each sequence are arranged in random order. Statistical analysis of the data shows that amino acids in the n, n + 1 and n, n + 3 relationship deviate from random expectation at the 1% level of significance. These relationships are consistent with known secondary structures; however, there are no amino acid pairs which obviously contribute to the non‐random result.
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U2 - 10.1111/j.1399-3011.1976.tb02488.x
DO - 10.1111/j.1399-3011.1976.tb02488.x
M3 - Article
C2 - 1270187
AN - SCOPUS:0017259027
SN - 0367-8377
VL - 8
SP - 125
EP - 130
JO - International Journal of Peptide and Protein Research
JF - International Journal of Peptide and Protein Research
IS - 2
ER -