TY - JOUR
T1 - Nontuberculous mycobacteria infections in immunosuppressed hosts
AU - Henkle, Emily
AU - Winthrop, Kevin L.
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Diseases and therapies that reduce cell-mediated immunity increase the risk of nontuberculous mycobacterial (NTM) disease. Extrapulmonary NTM disease, including disseminated, skin, and catheter-related disease, is more common in immunosuppressed than immunocompetent patients. Mycobacterium avium complex remains the most common cause of NTM infection, but rapid growers including Mycobacterium abscessus, Mycobacterium chelonae, and Mycobacterium fortuitum play an important role in skin and catheter-related infections. With the exception of antibiotic prophylaxis for AIDS patients, the prevention of NTM remains difficult. Management is complicated, involving restoration of immune function and removal of catheters in addition to treatment with species-specific antibiotics per current guidelines.
AB - Diseases and therapies that reduce cell-mediated immunity increase the risk of nontuberculous mycobacterial (NTM) disease. Extrapulmonary NTM disease, including disseminated, skin, and catheter-related disease, is more common in immunosuppressed than immunocompetent patients. Mycobacterium avium complex remains the most common cause of NTM infection, but rapid growers including Mycobacterium abscessus, Mycobacterium chelonae, and Mycobacterium fortuitum play an important role in skin and catheter-related infections. With the exception of antibiotic prophylaxis for AIDS patients, the prevention of NTM remains difficult. Management is complicated, involving restoration of immune function and removal of catheters in addition to treatment with species-specific antibiotics per current guidelines.
KW - Extrapulmonary nontuberculous mycobacteria
KW - Immunosuppressive therapy
KW - Mycobacterium avium
KW - Transplant
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U2 - 10.1016/j.ccm.2014.11.002
DO - 10.1016/j.ccm.2014.11.002
M3 - Review article
C2 - 25676522
AN - SCOPUS:84922447963
SN - 0272-5231
VL - 36
SP - 91
EP - 99
JO - Clinics in Chest Medicine
JF - Clinics in Chest Medicine
IS - 1
ER -