Norepinephrine transporter mRNA is elevated in the locus coeruleus following short- and long-term desipramine treatment

Patricia Szot; Alexandra Ashliegh; Ruth Kohen; Eric Petrie; Daniel M. Dorsa; Richard Veith

doi:10.1016/0006-8993(93)91281-V

Norepinephrine transporter mRNA is elevated in the locus coeruleus following short- and long-term desipramine treatment

Patricia Szot, Alexandra Ashliegh, Ruth Kohen, Eric Petrie, Daniel M. Dorsa, Richard Veith

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

In situ hybridization for the norepinephrine transporter (NET) mRNA was performed in animals receiving short-term (2 days) and long-term (4 weeks) treatment with desipramine (DMI; 10 mg/kg, intraperitoneal). Following short-term and long-term DMI treatment, a significant (P<0.05) increase in hybridizatino of ³⁵S-labeled oligonucleotides to NET mRNA in the locus coeruleus was observed compared to that observed in vehicle-treated animals. The mechanism of this increase in transporter mRNA or its involvement in the therapeutic effects of anti-depressants remains to be determined.

Original language	English (US)
Pages (from-to)	308-312
Number of pages	5
Journal	Brain research
Volume	618
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(93)91281-V
State	Published - Aug 6 1993
Externally published	Yes

Keywords

Desipramine
Locus coeruleus
Norepinephrine transporter mRNA
Transporter
Tricyclic antidepressant

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(93)91281-V

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title = "Norepinephrine transporter mRNA is elevated in the locus coeruleus following short- and long-term desipramine treatment",

abstract = "In situ hybridization for the norepinephrine transporter (NET) mRNA was performed in animals receiving short-term (2 days) and long-term (4 weeks) treatment with desipramine (DMI; 10 mg/kg, intraperitoneal). Following short-term and long-term DMI treatment, a significant (P<0.05) increase in hybridizatino of 35S-labeled oligonucleotides to NET mRNA in the locus coeruleus was observed compared to that observed in vehicle-treated animals. The mechanism of this increase in transporter mRNA or its involvement in the therapeutic effects of anti-depressants remains to be determined.",

keywords = "Desipramine, Locus coeruleus, Norepinephrine transporter mRNA, Transporter, Tricyclic antidepressant",

author = "Patricia Szot and Alexandra Ashliegh and Ruth Kohen and Eric Petrie and Dorsa, {Daniel M.} and Richard Veith",

note = "Funding Information: The authors wish to thank Raelee Parker and Sylvia White for their technical assistance. These studies were supported by NIH Grant 20311 and Research Service of the Department of Veterans Affairs.",

year = "1993",

month = aug,

day = "6",

doi = "10.1016/0006-8993(93)91281-V",

language = "English (US)",

volume = "618",

pages = "308--312",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Norepinephrine transporter mRNA is elevated in the locus coeruleus following short- and long-term desipramine treatment

AU - Szot, Patricia

AU - Ashliegh, Alexandra

AU - Kohen, Ruth

AU - Petrie, Eric

AU - Dorsa, Daniel M.

AU - Veith, Richard

N1 - Funding Information: The authors wish to thank Raelee Parker and Sylvia White for their technical assistance. These studies were supported by NIH Grant 20311 and Research Service of the Department of Veterans Affairs.

PY - 1993/8/6

Y1 - 1993/8/6

N2 - In situ hybridization for the norepinephrine transporter (NET) mRNA was performed in animals receiving short-term (2 days) and long-term (4 weeks) treatment with desipramine (DMI; 10 mg/kg, intraperitoneal). Following short-term and long-term DMI treatment, a significant (P<0.05) increase in hybridizatino of 35S-labeled oligonucleotides to NET mRNA in the locus coeruleus was observed compared to that observed in vehicle-treated animals. The mechanism of this increase in transporter mRNA or its involvement in the therapeutic effects of anti-depressants remains to be determined.

AB - In situ hybridization for the norepinephrine transporter (NET) mRNA was performed in animals receiving short-term (2 days) and long-term (4 weeks) treatment with desipramine (DMI; 10 mg/kg, intraperitoneal). Following short-term and long-term DMI treatment, a significant (P<0.05) increase in hybridizatino of 35S-labeled oligonucleotides to NET mRNA in the locus coeruleus was observed compared to that observed in vehicle-treated animals. The mechanism of this increase in transporter mRNA or its involvement in the therapeutic effects of anti-depressants remains to be determined.

KW - Desipramine

KW - Locus coeruleus

KW - Norepinephrine transporter mRNA

KW - Transporter

KW - Tricyclic antidepressant

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JF - Brain Research

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ER -

Norepinephrine transporter mRNA is elevated in the locus coeruleus following short- and long-term desipramine treatment

Abstract

Keywords

ASJC Scopus subject areas

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