TY - JOUR
T1 - Normative data for myocardial native T1 and extracellular volume fraction in children
AU - Pagano, Joseph J.
AU - Yim, Deane
AU - Lam, Christopher Z.
AU - Yoo, Shi Joon
AU - Seed, Mike
AU - Grosse-Wortmann, Lars
N1 - Publisher Copyright:
© RSNA, 2020.
PY - 2020/8
Y1 - 2020/8
N2 - Purpose: To establish normative data for myocardial T1, including extracellular volume (ECV) fraction, in healthy children. Materials and Methods: In this retrospective, single-center study, T1 mapping data were collected from 48 healthy pediatric patients (14 years ± 3 [standard deviation]; range, 9–18 years; 27 of 48 [56%] male) referred for cardiac screening 1.5-T MRI between 2014 and 2017. T1 relaxometry was performed using a 5(number of heartbeats [nHB])3 modified Look-Locker inversion recovery (MOLLI) sequence, where nHB was three to five heartbeats depending on the heart rate, and was repeated 15 minutes following the administra-tion of 0.2 mmol per kilogram of body weight of gadobenate dimeglumine, with 19 patients receiving contrast material. T1 values were calculated using a curve-fitting algorithm on average region-of-interest signal and corrected for imperfect inversion pulse effi-ciency. Comparisons within patients were performed with paired Student t test, between groups with unpaired Student t test or Mann-Whitney U test, and linear regression was performed to examine for associations with other variables. Results: Average native T1 was 1008 msec ± 31, with a nonsignificant increase in females (1017 msec ± 27 vs 1001 msec ± 33, P = .066). Average ECV was 20.8% ± 2.4, with a nonsignificant increase in values in females (21.7% ± 1.9 vs 20.0% ± 2.6, P = .123). T1 and ECV values were increased in the septum versus the free wall. Conclusion: Normative data are presented for myocardial native T1 and ECV using the MOLLI T1 mapping sequence at 1.5 T.
AB - Purpose: To establish normative data for myocardial T1, including extracellular volume (ECV) fraction, in healthy children. Materials and Methods: In this retrospective, single-center study, T1 mapping data were collected from 48 healthy pediatric patients (14 years ± 3 [standard deviation]; range, 9–18 years; 27 of 48 [56%] male) referred for cardiac screening 1.5-T MRI between 2014 and 2017. T1 relaxometry was performed using a 5(number of heartbeats [nHB])3 modified Look-Locker inversion recovery (MOLLI) sequence, where nHB was three to five heartbeats depending on the heart rate, and was repeated 15 minutes following the administra-tion of 0.2 mmol per kilogram of body weight of gadobenate dimeglumine, with 19 patients receiving contrast material. T1 values were calculated using a curve-fitting algorithm on average region-of-interest signal and corrected for imperfect inversion pulse effi-ciency. Comparisons within patients were performed with paired Student t test, between groups with unpaired Student t test or Mann-Whitney U test, and linear regression was performed to examine for associations with other variables. Results: Average native T1 was 1008 msec ± 31, with a nonsignificant increase in females (1017 msec ± 27 vs 1001 msec ± 33, P = .066). Average ECV was 20.8% ± 2.4, with a nonsignificant increase in values in females (21.7% ± 1.9 vs 20.0% ± 2.6, P = .123). T1 and ECV values were increased in the septum versus the free wall. Conclusion: Normative data are presented for myocardial native T1 and ECV using the MOLLI T1 mapping sequence at 1.5 T.
KW - Cardiac
KW - Left ventricle
KW - MR-imaging
KW - Pediatrics
KW - Tissue characterization
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U2 - 10.1148/ryct.2020190234
DO - 10.1148/ryct.2020190234
M3 - Article
AN - SCOPUS:85111541095
SN - 2638-6135
VL - 2
JO - Radiology: Cardiothoracic Imaging
JF - Radiology: Cardiothoracic Imaging
IS - 4
M1 - e190234
ER -