Novel 3,5-bis(arylidiene)-4-piperidone based monocarbonyl analogs of curcumin: Anticancer activity evaluation and mode of action study

Anuj Thakur; Sunny Manohar; Christian E. Vélez Gerena; Beatriz Zayas; Vineet Kumar; Sanjay V. Malhotra; Diwan S. Rawat

doi:10.1039/c3md00399j

Novel 3,5-bis(arylidiene)-4-piperidone based monocarbonyl analogs of curcumin: Anticancer activity evaluation and mode of action study

Anuj Thakur, Sunny Manohar, Christian E. Vélez Gerena, Beatriz Zayas, Vineet Kumar, Sanjay V. Malhotra, Diwan S. Rawat

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

A series of eighteen novel 3,5-bis(arylidiene)-4-piperidone based symmetrical monocarbonyl analogs of curcumin were synthesised and a subset was screened by National Cancer Institute (NCI), USA for their anticancer activity. Dose-response studies and the mechanism of action investigation suggest that most active compounds are apoptosis inducers. This journal is

Original language	English (US)
Pages (from-to)	576-586
Number of pages	11
Journal	MedChemComm
Volume	5
Issue number	5
DOIs	https://doi.org/10.1039/c3md00399j
State	Published - May 2014
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

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AU - Vélez Gerena, Christian E.

AU - Zayas, Beatriz

AU - Kumar, Vineet

AU - Malhotra, Sanjay V.

AU - Rawat, Diwan S.

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AB - A series of eighteen novel 3,5-bis(arylidiene)-4-piperidone based symmetrical monocarbonyl analogs of curcumin were synthesised and a subset was screened by National Cancer Institute (NCI), USA for their anticancer activity. Dose-response studies and the mechanism of action investigation suggest that most active compounds are apoptosis inducers. This journal is

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Novel 3,5-bis(arylidiene)-4-piperidone based monocarbonyl analogs of curcumin: Anticancer activity evaluation and mode of action study

Abstract

ASJC Scopus subject areas

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