Novel expression of hypothalamic neuropeptide Y during postnatal development in the rat

Lori K. Singer; Joel Kuper; Rebecca S. Brogan; M. Susan Smith; Kevin L. Grove

doi:10.1097/00001756-200004070-00034

Novel expression of hypothalamic neuropeptide Y during postnatal development in the rat

Lori K. Singer, Joel Kuper, Rebecca S. Brogan, M. Susan Smith, Kevin L. Grove

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Neuropeptide Y (NPY) is a potent orexigenic peptide. In the normal adult rat, hypothalamic NPY mRNA expression is limited to the arcuate nucleus (ARH). The purposes of this study was to characterize the developmental expression of NPY mRNA in the hypothalamus of the rat. In contrast to the normal adult rat, NPY mRNA was observed in the ARH, the dorsomedial hypothalamic nucleus (DMH) and the perifornical region (PFR) during development. NPY mRNA expression in all three regions increased progressively from postnatal days 0-4 (P0-4) to reach maximum levels at P16 and subsequently decreased to near adult levels by P30. The unique expression of NPY mRNA in the PFR and DMH may be important in establishing the proper management of energy homeostasis and body weight in the adult animal. (C) 2000 Lippincott Williams and Wilkins.

Original language	English (US)
Pages (from-to)	1075-1080
Number of pages	6
Journal	NeuroReport
Volume	11
Issue number	5
DOIs	https://doi.org/10.1097/00001756-200004070-00034
State	Published - Apr 7 2000

Keywords

Food intake
Hypothalamus
In situ hybridization
Neuropeptide Y
Perifornical region
Postnatal development

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/00001756-200004070-00034

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title = "Novel expression of hypothalamic neuropeptide Y during postnatal development in the rat",

abstract = "Neuropeptide Y (NPY) is a potent orexigenic peptide. In the normal adult rat, hypothalamic NPY mRNA expression is limited to the arcuate nucleus (ARH). The purposes of this study was to characterize the developmental expression of NPY mRNA in the hypothalamus of the rat. In contrast to the normal adult rat, NPY mRNA was observed in the ARH, the dorsomedial hypothalamic nucleus (DMH) and the perifornical region (PFR) during development. NPY mRNA expression in all three regions increased progressively from postnatal days 0-4 (P0-4) to reach maximum levels at P16 and subsequently decreased to near adult levels by P30. The unique expression of NPY mRNA in the PFR and DMH may be important in establishing the proper management of energy homeostasis and body weight in the adult animal. (C) 2000 Lippincott Williams and Wilkins.",

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AU - Singer, Lori K.

AU - Kuper, Joel

AU - Brogan, Rebecca S.

AU - Smith, M. Susan

AU - Grove, Kevin L.

PY - 2000/4/7

Y1 - 2000/4/7

N2 - Neuropeptide Y (NPY) is a potent orexigenic peptide. In the normal adult rat, hypothalamic NPY mRNA expression is limited to the arcuate nucleus (ARH). The purposes of this study was to characterize the developmental expression of NPY mRNA in the hypothalamus of the rat. In contrast to the normal adult rat, NPY mRNA was observed in the ARH, the dorsomedial hypothalamic nucleus (DMH) and the perifornical region (PFR) during development. NPY mRNA expression in all three regions increased progressively from postnatal days 0-4 (P0-4) to reach maximum levels at P16 and subsequently decreased to near adult levels by P30. The unique expression of NPY mRNA in the PFR and DMH may be important in establishing the proper management of energy homeostasis and body weight in the adult animal. (C) 2000 Lippincott Williams and Wilkins.

AB - Neuropeptide Y (NPY) is a potent orexigenic peptide. In the normal adult rat, hypothalamic NPY mRNA expression is limited to the arcuate nucleus (ARH). The purposes of this study was to characterize the developmental expression of NPY mRNA in the hypothalamus of the rat. In contrast to the normal adult rat, NPY mRNA was observed in the ARH, the dorsomedial hypothalamic nucleus (DMH) and the perifornical region (PFR) during development. NPY mRNA expression in all three regions increased progressively from postnatal days 0-4 (P0-4) to reach maximum levels at P16 and subsequently decreased to near adult levels by P30. The unique expression of NPY mRNA in the PFR and DMH may be important in establishing the proper management of energy homeostasis and body weight in the adult animal. (C) 2000 Lippincott Williams and Wilkins.

KW - Food intake

KW - Hypothalamus

KW - In situ hybridization

KW - Neuropeptide Y

KW - Perifornical region

KW - Postnatal development

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JO - NeuroReport

JF - NeuroReport

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ER -

Novel expression of hypothalamic neuropeptide Y during postnatal development in the rat

Abstract

Keywords

ASJC Scopus subject areas

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