TY - JOUR
T1 - Novel image-novel location object recognition task sensitive to age-related cognitive decline in nondemented elderly
AU - Haley, Gwendolen E.
AU - Berteau-Pavy, Frederique
AU - Berteau-Pavy, Daphnee
AU - Raber, Jacob
N1 - Funding Information:
Acknowledgments This work was funded by EMF AG-NS-0201, the Medical Research Foundation of Oregon, a pilot project of the Oregon Alzheimer’s Disease Center NIH P30 AG008017, PHS grant 5M01 RR000334, NIA T32-AG023477, NIH R01 AG024059, Oregon Center for Aging and Alzheimer’s Disease Center NIH P30 AG024978, Oregon Alzheimer’s Disease Center NIH P30 AG008017. We also acknowledge Bioengineering Research Partnership and Intelligent Systems for Assessing Aging Changes.
PY - 2012/2
Y1 - 2012/2
N2 - Traditional tests used in the clinic to identify dementia, such as the mini-mental state examination (MMSE), are useful to identify severe cognitive impairments but might be less sensitive to detect more subtle age-related cognitive changes. Previously, the novel image-novel location (NINL) object recognition test was shown to be sensitive to detect effects of apolipoprotein E4, a risk factor for developing age-related cognitive decline and Alzheimer's disease, in nondemented elderly. In the present longitudinal study, performance on the MMSE and the NINL tests were compared over a 4-year period. Individual NINL scores over this period were highly correlated. In addition, while MMSE scores did not change over the 4-year period, NINL scores did. In a final testing session of a subset of the participants, NINL scores correlated with logical memory and word recall lists, cognitive tasks used to detect dementia in the clinic, as well as clinical dementia rating scales. These results support that the NINL might be a valuable tool to assess age-related cognitive decline.
AB - Traditional tests used in the clinic to identify dementia, such as the mini-mental state examination (MMSE), are useful to identify severe cognitive impairments but might be less sensitive to detect more subtle age-related cognitive changes. Previously, the novel image-novel location (NINL) object recognition test was shown to be sensitive to detect effects of apolipoprotein E4, a risk factor for developing age-related cognitive decline and Alzheimer's disease, in nondemented elderly. In the present longitudinal study, performance on the MMSE and the NINL tests were compared over a 4-year period. Individual NINL scores over this period were highly correlated. In addition, while MMSE scores did not change over the 4-year period, NINL scores did. In a final testing session of a subset of the participants, NINL scores correlated with logical memory and word recall lists, cognitive tasks used to detect dementia in the clinic, as well as clinical dementia rating scales. These results support that the NINL might be a valuable tool to assess age-related cognitive decline.
KW - Cognitive aging
KW - Dementia
KW - Object recognition
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U2 - 10.1007/s11357-010-9204-2
DO - 10.1007/s11357-010-9204-2
M3 - Article
C2 - 21234692
AN - SCOPUS:84862326623
SN - 0161-9152
VL - 34
SP - 1
EP - 10
JO - Age
JF - Age
IS - 1
ER -