Observations on intramembrane charge movements in skeletal muscle.

W. Almers

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Using signal-averaging techniques, one can record small membrane currents which remain even after blockage of the ionic currents which accompany electrical excitation in muscle. These residual currents probably represent the reorientation of charged molecules inside the membrane in response to a change in membrane potential. Two operationally separable types of intramembrane charge movement in muscle are described, one of which may play a role in excitation-contraction coupling. Studies of tetrodotoxin binding to muscle indicate that "sodium gating current" is unlikely to contribute significantly to either type of charge movement.

Original languageEnglish (US)
Pages (from-to)507-513
Number of pages7
JournalPhilosophical transactions of the Royal Society of London. Series B, Biological sciences
Issue number908
StatePublished - Jun 10 1975
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences


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