Ocular abnormalities associated with cutaneous melanoma and vitiligolike leukoderma

M. A. Chang, G. Fournier, H. K. Koh, A. J. Sober, H. Nakagawa, T. B. Fitzpatrick, D. M. Albert

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Several varieties of ocular pathology are associated with acquired cutaneous hypomelanosis (leukoderma; vitiligo). Our current study was undertaken to investigate the relationship between ophthalmologic disorders and a specific depigmentary phenomenon, the vitiligolike leukoderma of cutaneous melanoma. Over the past 14 years, eight patients with cutaneous melanoma and widespread areas of hypopigmentation were identified at the Pigmented Lesion Clinic of the Massachusetts General Hospital. The seven patients who underwent ophthalmologic examination had pigment-related ocular abnormalities. Among these were inflammations of the uveal tract in three patients, heterochromia in two, halo nevi of the choroid in one, and hypopigmentation and/or atrophy of the retinal pigment epithelium or choroid in four. Our findings demonstrate that ocular disease may be a component in a syndrome consisting also of cutaneous melanoma and vitiligolike leukoderma and suggest the need for complete ophthalmologic examinations in patients with melanoma and leukoderma.

Original languageEnglish (US)
Pages (from-to)529-535
Number of pages7
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Issue number6
StatePublished - Nov 1986
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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