TY - JOUR
T1 - Oculogyric crisis in patients taking cetirizine
AU - Fraunfelder, Frederick W.
AU - Fraunfelder, Frederick T.
N1 - Funding Information:
This study was supported in part by an unrestricted grant from Research to Prevent Blindness, New York, New York, and by the National Registry of Drug-Induced Ocular Side Effects (www.eyedrugregistry.com), Casey Eye Institute, Oregon Health and Science University, Portland, Oregon.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2004/2
Y1 - 2004/2
N2 - PURPOSE: To report oculogyric crisis in patients receiving cetirizine and inform clinicians on the characteristics of this drug-induced ocular side effect. METHODS: For this retrospective, observational case series, case reports were collected from the National Registry of Drug-Induced Ocular Side Effects (Casey Eye Institute, Portland, Oregon). The World Health Organization Causality Assessment Guide of Suspected Adverse Reactions was used to categorize the cases. RESULTS: Nine cases were reported, with eight occurring in the pediatric age group. Dosage ranged from 5 to 10 mg orally and onset of symptoms ranged from 3 to 184 days. Six cases of oculogyric crisis had positive rechallenge data. Eight cases had complete neurologic consultation including radiographic studies. CONCLUSIONS: Cetirizine can cause oculogyric crisis, especially in the pediatric age group. Extensive neurologic workups may be avoided if clinicians recognize this drug-induced ocular side effect.
AB - PURPOSE: To report oculogyric crisis in patients receiving cetirizine and inform clinicians on the characteristics of this drug-induced ocular side effect. METHODS: For this retrospective, observational case series, case reports were collected from the National Registry of Drug-Induced Ocular Side Effects (Casey Eye Institute, Portland, Oregon). The World Health Organization Causality Assessment Guide of Suspected Adverse Reactions was used to categorize the cases. RESULTS: Nine cases were reported, with eight occurring in the pediatric age group. Dosage ranged from 5 to 10 mg orally and onset of symptoms ranged from 3 to 184 days. Six cases of oculogyric crisis had positive rechallenge data. Eight cases had complete neurologic consultation including radiographic studies. CONCLUSIONS: Cetirizine can cause oculogyric crisis, especially in the pediatric age group. Extensive neurologic workups may be avoided if clinicians recognize this drug-induced ocular side effect.
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U2 - 10.1016/S0002-9394(03)00869-9
DO - 10.1016/S0002-9394(03)00869-9
M3 - Article
C2 - 14962433
AN - SCOPUS:1242338768
SN - 0002-9394
VL - 137
SP - 355
EP - 357
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 2
ER -