TY - JOUR
T1 - Oldest-old healthy brain function
T2 - The genomic potentials
AU - Kaye, Jeffrey A.
PY - 1997/10
Y1 - 1997/10
N2 - There will be a remarkable increase in the number of people older than 85 years-the oldest-old-in the next 50 years. This age group is especially vulnerable to increasing disabilities, many of which are the result of the aging nervous system. Among these aging changes, the mOSt devastating and likely to have the greatest impact on our society is the development of dementia. Since dementia is present in the majority of those who live to the current maximum of the human life span, this suggests that dementia is a normal aging event. Although the exact causes of this common cognitive failure in the oldest-old are not known, there is recent evidence from genetic studies of aging and Alzheimer disease to suggest that there are a number of susceptibility genes that may modify or delay the onset of late- life brain failure. These gene families form a natural target for devising strategies for significantly delaying the onset of late-life dementia.
AB - There will be a remarkable increase in the number of people older than 85 years-the oldest-old-in the next 50 years. This age group is especially vulnerable to increasing disabilities, many of which are the result of the aging nervous system. Among these aging changes, the mOSt devastating and likely to have the greatest impact on our society is the development of dementia. Since dementia is present in the majority of those who live to the current maximum of the human life span, this suggests that dementia is a normal aging event. Although the exact causes of this common cognitive failure in the oldest-old are not known, there is recent evidence from genetic studies of aging and Alzheimer disease to suggest that there are a number of susceptibility genes that may modify or delay the onset of late- life brain failure. These gene families form a natural target for devising strategies for significantly delaying the onset of late-life dementia.
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U2 - 10.1001/archneur.1997.00550220027009
DO - 10.1001/archneur.1997.00550220027009
M3 - Review article
C2 - 9341566
AN - SCOPUS:0030850569
SN - 0003-9942
VL - 54
SP - 1217
EP - 1221
JO - Archives of Neurology
JF - Archives of Neurology
IS - 10
ER -