TY - JOUR
T1 - Oligoclonal Bands in Multiple System Atrophy
T2 - Case Report and Proposed Mechanisms of Immunogenicity
AU - Neilson, Lee E.
AU - Hollen, Christopher
AU - Hiller, Amie
AU - Wooliscroft, Lindsey
N1 - Publisher Copyright:
Copyright © 2022 Neilson, Hollen, Hiller and Wooliscroft.
PY - 2022/2/28
Y1 - 2022/2/28
N2 - Multiple System Atrophy (MSA) is a neurodegenerative disease with heterogeneous manifestations and is therefore difficult to diagnose definitively. Because of this, oftentimes an extensive workup for mimickers is undertaken. We herein report a case where the history and cerebrospinal fluid (CSF) findings of oligoclonal bands suggested an inflammatory disorder. Immunomodulatory therapy failed to ameliorate symptoms or alter the trajectory of continued physical decline, prompting re-visitation of the diagnosis. Oligoclonal bands, while generally viewed as specific to multiple sclerosis or other inflammatory conditions, may be seen in other disease processes. Therefore, this finding should not exclude consideration of neurodegenerative disease.
AB - Multiple System Atrophy (MSA) is a neurodegenerative disease with heterogeneous manifestations and is therefore difficult to diagnose definitively. Because of this, oftentimes an extensive workup for mimickers is undertaken. We herein report a case where the history and cerebrospinal fluid (CSF) findings of oligoclonal bands suggested an inflammatory disorder. Immunomodulatory therapy failed to ameliorate symptoms or alter the trajectory of continued physical decline, prompting re-visitation of the diagnosis. Oligoclonal bands, while generally viewed as specific to multiple sclerosis or other inflammatory conditions, may be seen in other disease processes. Therefore, this finding should not exclude consideration of neurodegenerative disease.
KW - ataxia
KW - multiple system atrophy
KW - neurodegenerative disease
KW - neuroinflammation
KW - oligoclonal band
UR - http://www.scopus.com/inward/record.url?scp=85127067134&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85127067134&partnerID=8YFLogxK
U2 - 10.3389/fnins.2022.852939
DO - 10.3389/fnins.2022.852939
M3 - Article
AN - SCOPUS:85127067134
SN - 1662-4548
VL - 16
JO - Frontiers in Neuroscience
JF - Frontiers in Neuroscience
M1 - 852939
ER -