Onset and Patterns of Disease Progression of Peri-Implant Diseases: A Narrative Review

Annika Van der Werf, Fernando Suárez López del Amo, Carlos Garaicoa-Pazmino

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: The aim of this narrative review was to present relevant evidence regarding the onset and patterns of disease progression of peri-implantitis lesions based on current experimental and observational studies. Recent Findings: The conversion from peri-implant mucositis to peri-implantitis continues to be not fully elucidated. In vivo studies revealed that peri-implantitis displays a progressive destructive nature dependent to the experimental model. Human peri-implantitis lesions follow a non-linear but accelerating pattern of disease progression occurring mostly within the first 3 years of function. Based on the available scientific evidence, histopathological differences between peri-implantitis and periodontitis lesions might be responsible for the dissimilarities in the onset and progression of these two conditions. Future research evaluating the pathogenesis and longitudinal disease attributes of peri-implant diseases is necessary to fill gaps in knowledge. Summary: Scarce scientific evidence remains available in relation to the onset and progression of peri-implant diseases.

Original languageEnglish (US)
Pages (from-to)205-210
Number of pages6
JournalCurrent Oral Health Reports
Issue number4
StatePublished - Dec 2022
Externally publishedYes


  • Dental implants
  • Disease attributes
  • Disease progression
  • Early implant failure
  • Peri-implant mucositis
  • Peri-implantitis

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Immunology and Microbiology (miscellaneous)


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