Ontogenetic changes in vasopressin binding site distribution in rat brain: An autoradiographic study

Frances M. Petracca; Denis G. Baskin; Jaime Diaz; Daniel M. Dorsa

doi:10.1016/0165-3806(86)90065-9

Ontogenetic changes in vasopressin binding site distribution in rat brain: An autoradiographic study

Frances M. Petracca
, Denis G. Baskin
, Jaime Diaz
, Daniel M. Dorsa

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Binding sites for [³H]vasopressin were identified in brains of neonatal (days 0-23) and adult (90 day) Long-Evans and Brattleboro rats, using a technique of in vitro receptor autoradiography. Results indicate that the regional distribution of binding sites for [³H]vasopressin in the brain changes markedly during postnatal development. Binding sites in the septum proliferated slowly to attain adult distribution in the dorsal and lateral septum, while in other regions, such as the caudate, hippocampus and cingulate gyrus, intense labeling appeared early in development but disappeared by adulthood. In the amygdala, binding did not change during postnatal development. Binding sites in the septum appeared before vasopressinergic fibers are present. Also, binding was present for vasopressin in regions which have not yet been reported to receive vasopressinergic innervation. Therefore, it is proposed that the presence of binding sites for vasopressin is independent of the presence of vasopressin itself. This hypothesis is supported by labeling in the Brattleboro rat which was comparable to that in the Long-Evans.

Original language	English (US)
Pages (from-to)	63-68
Number of pages	6
Journal	Developmental Brain Research
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/0165-3806(86)90065-9
State	Published - Jul 1986
Externally published	Yes

Funding

The authors wish to thank Chare Vathanaprida, Henderson Mar and John Breininger for technical assistance. This work was supported by N1H Grant NS20311 and by the Medical Research Service of the Veteran's Administration.

Funders	Funder number
Veteran's Administration
National Institute of Neurological Disorders and Stroke	R01NS020311

Keywords

Brattleboro rat
autoradiography
development
receptor
vasopressin

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

Access to Document

10.1016/0165-3806(86)90065-9

Cite this

@article{eb12f954fc154046bca0e3e8ae20dd31,

title = "Ontogenetic changes in vasopressin binding site distribution in rat brain: An autoradiographic study",

abstract = "Binding sites for [3H]vasopressin were identified in brains of neonatal (days 0-23) and adult (90 day) Long-Evans and Brattleboro rats, using a technique of in vitro receptor autoradiography. Results indicate that the regional distribution of binding sites for [3H]vasopressin in the brain changes markedly during postnatal development. Binding sites in the septum proliferated slowly to attain adult distribution in the dorsal and lateral septum, while in other regions, such as the caudate, hippocampus and cingulate gyrus, intense labeling appeared early in development but disappeared by adulthood. In the amygdala, binding did not change during postnatal development. Binding sites in the septum appeared before vasopressinergic fibers are present. Also, binding was present for vasopressin in regions which have not yet been reported to receive vasopressinergic innervation. Therefore, it is proposed that the presence of binding sites for vasopressin is independent of the presence of vasopressin itself. This hypothesis is supported by labeling in the Brattleboro rat which was comparable to that in the Long-Evans.",

keywords = "Brattleboro rat, autoradiography, development, receptor, vasopressin",

author = "Petracca, \{Frances M.\} and Baskin, \{Denis G.\} and Jaime Diaz and Dorsa, \{Daniel M.\}",

note = "Funding Information: The authors wish to thank Chare Vathanaprida, Henderson Mar and John Breininger for technical assistance. This work was supported by N1H Grant NS20311 and by the Medical Research Service of the Veteran's Administration.",

year = "1986",

month = jul,

doi = "10.1016/0165-3806(86)90065-9",

language = "English (US)",

volume = "28",

pages = "63--68",

journal = "Developmental Brain Research",

issn = "0165-3806",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Ontogenetic changes in vasopressin binding site distribution in rat brain

T2 - An autoradiographic study

AU - Petracca, Frances M.

AU - Baskin, Denis G.

AU - Diaz, Jaime

AU - Dorsa, Daniel M.

N1 - Funding Information: The authors wish to thank Chare Vathanaprida, Henderson Mar and John Breininger for technical assistance. This work was supported by N1H Grant NS20311 and by the Medical Research Service of the Veteran's Administration.

PY - 1986/7

Y1 - 1986/7

N2 - Binding sites for [3H]vasopressin were identified in brains of neonatal (days 0-23) and adult (90 day) Long-Evans and Brattleboro rats, using a technique of in vitro receptor autoradiography. Results indicate that the regional distribution of binding sites for [3H]vasopressin in the brain changes markedly during postnatal development. Binding sites in the septum proliferated slowly to attain adult distribution in the dorsal and lateral septum, while in other regions, such as the caudate, hippocampus and cingulate gyrus, intense labeling appeared early in development but disappeared by adulthood. In the amygdala, binding did not change during postnatal development. Binding sites in the septum appeared before vasopressinergic fibers are present. Also, binding was present for vasopressin in regions which have not yet been reported to receive vasopressinergic innervation. Therefore, it is proposed that the presence of binding sites for vasopressin is independent of the presence of vasopressin itself. This hypothesis is supported by labeling in the Brattleboro rat which was comparable to that in the Long-Evans.

AB - Binding sites for [3H]vasopressin were identified in brains of neonatal (days 0-23) and adult (90 day) Long-Evans and Brattleboro rats, using a technique of in vitro receptor autoradiography. Results indicate that the regional distribution of binding sites for [3H]vasopressin in the brain changes markedly during postnatal development. Binding sites in the septum proliferated slowly to attain adult distribution in the dorsal and lateral septum, while in other regions, such as the caudate, hippocampus and cingulate gyrus, intense labeling appeared early in development but disappeared by adulthood. In the amygdala, binding did not change during postnatal development. Binding sites in the septum appeared before vasopressinergic fibers are present. Also, binding was present for vasopressin in regions which have not yet been reported to receive vasopressinergic innervation. Therefore, it is proposed that the presence of binding sites for vasopressin is independent of the presence of vasopressin itself. This hypothesis is supported by labeling in the Brattleboro rat which was comparable to that in the Long-Evans.

KW - Brattleboro rat

KW - autoradiography

KW - development

KW - receptor

KW - vasopressin

UR - https://www.scopus.com/pages/publications/0022746366

UR - https://www.scopus.com/pages/publications/0022746366#tab=citedBy

U2 - 10.1016/0165-3806(86)90065-9

DO - 10.1016/0165-3806(86)90065-9

M3 - Article

C2 - 3730894

AN - SCOPUS:0022746366

SN - 0165-3806

VL - 28

SP - 63

EP - 68

JO - Developmental Brain Research

JF - Developmental Brain Research

IS - 1

ER -

Ontogenetic changes in vasopressin binding site distribution in rat brain: An autoradiographic study

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this