Ontogeny of ethanol-induced locomotor activity and hypothermia differences in selectively bred FAST and SLOW mice

Robin D. Wood; Elaine H. Shen; Julia A. Chester; Tamara J. Phillips

doi:10.1016/S0091-3057(98)00158-0

Ontogeny of ethanol-induced locomotor activity and hypothermia differences in selectively bred FAST and SLOW mice

Robin D. Wood
, Elaine H. Shen
, Julia A. Chester
, Tamara J. Phillips

Behavioral Neuroscience

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The replicate lines of selectively bred FAST and SLOW mice differ in locomotor response to 2 g/kg ethanol (EtOH). FAST mice show enhanced locomotion; SLOW mice exhibit no change or locomotor depression. Little is known about the responses of FAST and SLOW mice to EtOH during development. We assessed the locomotor responses of FAST and SLOW mice at postnatal days (P) 10, 15, 30, and 60. A genetically correlated response, EtOH-induced hypothermia, was also investigated. Although all animals demonstrated their respective selection phenotypes in adulthood, developing FAST mice exhibited ethanol stimulation by P15 (replicate 1) or P30 (replicate 2). At these ages, responses of FAST mice differed from those of SLOW. The stimulant response in FAST mice was adult-like at P30. EtOH-induced hypothermia was seen in SLOW mice by P15. These data suggest that sensitivity to the locomotor stimulant effects of EtOH changes during postnatal development, and may mirror developmental profiles for certain neurotransmitter systems. Copyright (C) 1999 Elsevier Science Inc.

Original language	English (US)
Pages (from-to)	339-347
Number of pages	9
Journal	Pharmacology Biochemistry and Behavior
Volume	62
Issue number	2
DOIs	https://doi.org/10.1016/S0091-3057(98)00158-0
State	Published - Feb 1999

Funding

This work was supported by a grant from the Department of Veterans Affairs (T. J. P.) and by NIAAA Grants AA05493-01 (R. D. W.), and AA10760 (T. J. P.). We gratefully acknowledge the technical assistance of Heather S. Hain, Sue Burkhart-Kasch, and Charlotte D. Wenger, and the thoughtful comments provided by Dr. John C. Crabbe on an earlier version of this manuscript.

Funders	Funder number
National Institute of Alcohol Abuse and Alcoholism	P50AA010760, AA05493-01
U.S. Department of Veterans Affairs

Keywords

Development
Ethanol
FAST and SLOW mice
Hypothermia
Locomotor activity
Ontogeny
Pharmacogenetics
Selected mouse lines

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/S0091-3057(98)00158-0

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title = "Ontogeny of ethanol-induced locomotor activity and hypothermia differences in selectively bred FAST and SLOW mice",

abstract = "The replicate lines of selectively bred FAST and SLOW mice differ in locomotor response to 2 g/kg ethanol (EtOH). FAST mice show enhanced locomotion; SLOW mice exhibit no change or locomotor depression. Little is known about the responses of FAST and SLOW mice to EtOH during development. We assessed the locomotor responses of FAST and SLOW mice at postnatal days (P) 10, 15, 30, and 60. A genetically correlated response, EtOH-induced hypothermia, was also investigated. Although all animals demonstrated their respective selection phenotypes in adulthood, developing FAST mice exhibited ethanol stimulation by P15 (replicate 1) or P30 (replicate 2). At these ages, responses of FAST mice differed from those of SLOW. The stimulant response in FAST mice was adult-like at P30. EtOH-induced hypothermia was seen in SLOW mice by P15. These data suggest that sensitivity to the locomotor stimulant effects of EtOH changes during postnatal development, and may mirror developmental profiles for certain neurotransmitter systems. Copyright (C) 1999 Elsevier Science Inc.",

keywords = "Development, Ethanol, FAST and SLOW mice, Hypothermia, Locomotor activity, Ontogeny, Pharmacogenetics, Selected mouse lines",

author = "Wood, \{Robin D.\} and Shen, \{Elaine H.\} and Chester, \{Julia A.\} and Phillips, \{Tamara J.\}",

note = "Funding Information: This work was supported by a grant from the Department of Veterans Affairs (T. J. P.) and by NIAAA Grants AA05493-01 (R. D. W.), and AA10760 (T. J. P.). We gratefully acknowledge the technical assistance of Heather S. Hain, Sue Burkhart-Kasch, and Charlotte D. Wenger, and the thoughtful comments provided by Dr. John C. Crabbe on an earlier version of this manuscript.",

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N2 - The replicate lines of selectively bred FAST and SLOW mice differ in locomotor response to 2 g/kg ethanol (EtOH). FAST mice show enhanced locomotion; SLOW mice exhibit no change or locomotor depression. Little is known about the responses of FAST and SLOW mice to EtOH during development. We assessed the locomotor responses of FAST and SLOW mice at postnatal days (P) 10, 15, 30, and 60. A genetically correlated response, EtOH-induced hypothermia, was also investigated. Although all animals demonstrated their respective selection phenotypes in adulthood, developing FAST mice exhibited ethanol stimulation by P15 (replicate 1) or P30 (replicate 2). At these ages, responses of FAST mice differed from those of SLOW. The stimulant response in FAST mice was adult-like at P30. EtOH-induced hypothermia was seen in SLOW mice by P15. These data suggest that sensitivity to the locomotor stimulant effects of EtOH changes during postnatal development, and may mirror developmental profiles for certain neurotransmitter systems. Copyright (C) 1999 Elsevier Science Inc.

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KW - Hypothermia

KW - Locomotor activity

KW - Ontogeny

KW - Pharmacogenetics

KW - Selected mouse lines

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Ontogeny of ethanol-induced locomotor activity and hypothermia differences in selectively bred FAST and SLOW mice

Abstract

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Keywords

ASJC Scopus subject areas

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