Optical coherence tomography artifacts are associated with adaptive optics scanning light ophthalmoscopy success in achromatopsia

Katie M. Litts; Erica N. Woertz; Michalis Georgiou; Emily J. Patterson; Byron L. Lam; Gerald A. Fishman; Mark E. Pennesi; Christine N. Kay; William W. Hauswirth; Michel Michaelides; Joseph Carroll

doi:10.1167/tvst.10.1.11

Optical coherence tomography artifacts are associated with adaptive optics scanning light ophthalmoscopy success in achromatopsia

Katie M. Litts
, Erica N. Woertz
, Michalis Georgiou
, Emily J. Patterson
, Byron L. Lam
, Gerald A. Fishman
, Mark E. Pennesi
, Christine N. Kay
, William W. Hauswirth
, Michel Michaelides
, Joseph Carroll

Ophthalmology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Purpose: To determine whether artifacts in optical coherence tomography (OCT) images are associated with the success or failure of adaptive optics scanning light ophthalmoscopy (AOSLO) imaging in subjects with achromatopsia (ACHM). Methods: Previously acquired OCT and non-confocal, split-detector AOSLO images from one eye of 66 subjects with genetically confirmed achromatopsia (15 CNGA3 and 51 CNGB3) were reviewed along with best-corrected visual acuity (BCVA) and axial length. OCT artifacts in interpolated vertical volumes from CIRRUS macular cubes were divided into four categories: (1) none or minimal, (2) clear and low frequency, (3) low amplitude and high frequency, and (4) high amplitude and high frequency. Each vertical volume was assessed once by two observers. AOSLO success was defined as sufficient image quality in split-detector images at the fovea to assess cone quantity. Results: There was excellent agreement between the two observers for assessing OCT artifact severity category (weighted kappa = 0.88). Overall, AOSLO success was 47%. For subjects with OCT artifact severity category 1, AOSLO success was 65%; for category 2, 47%; for category 3, 11%; and for category 4, 0%. There was a significant association between OCT artifact severity category and AOSLO success (P = 0.0002). Neither BCVA nor axial length was associated with AOSLO success (P = 0.07 and P = 0.75, respectively). Conclusions: Artifacts in OCT volumes are associated with AOSLO success in ACHM. Subjects with less severe OCT artifacts are more likely to be good candidates for AOSLO imaging, whereas AOSLO was successful in only 7% of subjects with category 3 or 4 OCT artifacts. These results may be useful in guiding patient selection for AOSLO imaging. Translational Relevance: Using OCT to prescreen patients could be a valuable tool for clinical trials that utilize AOSLO to reduce costs and decrease patient testing burden.

Original language	English (US)
Article number	11
Pages (from-to)	1-11
Number of pages	11
Journal	Translational Vision Science and Technology
Volume	10
Issue number	1
DOIs	https://doi.org/10.1167/tvst.10.1.11
State	Published - 2021

Funding

Supported by grants from the National Eye Institute, National Institutes of Health (NIH) (R01EY017607, P30EY010572, R24EY022023, T32EY014537, T32GM080202, and F32EY029148) and National Center for Advancing Translational Sciences, NIH (UL1TR001436), as well as unrestricted grants from Research to Prevent Blindness to the University of Florida and Casey Eye Institute, and the Foundation Fighting Blindness. This investigation was conducted in part in a facility constructed with support from a Research Facilities Improvement Program grant (C06RR016511) from the National Center for Research Resources, NIH. Additional support was provided by the Gene and Ruth Posner Foundation and Achroma Corp. Additional support was provided by grants from the National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL

Funders	Funder number
Achroma Corp.
National Eye Institute and Casey Eye Institute
Gene and Ruth Posner Foundation
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health	F32EY029148, T32EY014537, T32GM080202, R24EY022023, P30EY010572, R01EY017607
National Eye Institute and Casey Eye Institute
National Center for Research Resources
Foundation Fighting Blindness	C06RR016511
Research to Prevent Blindness
National Center for Advancing Translational Sciences	UL1TR001436
University of Southern Florida
University College London Hospital/University College London
Moorfields Eye Hospital NHS Foundation Trust
National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology

Keywords

Achromatopsia
Adaptive optics
Inherited retinal disease
Optical coherence tomography

ASJC Scopus subject areas

Biomedical Engineering
Ophthalmology

Access to Document

10.1167/tvst.10.1.11

Cite this

Litts, K. M., Woertz, E. N., Georgiou, M., Patterson, E. J., Lam, B. L., Fishman, G. A., Pennesi, M. E., Kay, C. N., Hauswirth, W. W., Michaelides, M., & Carroll, J. (2021). Optical coherence tomography artifacts are associated with adaptive optics scanning light ophthalmoscopy success in achromatopsia. Translational Vision Science and Technology, 10(1), 1-11. Article 11. https://doi.org/10.1167/tvst.10.1.11

Litts, KM, Woertz, EN, Georgiou, M, Patterson, EJ, Lam, BL, Fishman, GA, Pennesi, ME, Kay, CN, Hauswirth, WW, Michaelides, M & Carroll, J 2021, 'Optical coherence tomography artifacts are associated with adaptive optics scanning light ophthalmoscopy success in achromatopsia', Translational Vision Science and Technology, vol. 10, no. 1, 11, pp. 1-11. https://doi.org/10.1167/tvst.10.1.11

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abstract = "Purpose: To determine whether artifacts in optical coherence tomography (OCT) images are associated with the success or failure of adaptive optics scanning light ophthalmoscopy (AOSLO) imaging in subjects with achromatopsia (ACHM). Methods: Previously acquired OCT and non-confocal, split-detector AOSLO images from one eye of 66 subjects with genetically confirmed achromatopsia (15 CNGA3 and 51 CNGB3) were reviewed along with best-corrected visual acuity (BCVA) and axial length. OCT artifacts in interpolated vertical volumes from CIRRUS macular cubes were divided into four categories: (1) none or minimal, (2) clear and low frequency, (3) low amplitude and high frequency, and (4) high amplitude and high frequency. Each vertical volume was assessed once by two observers. AOSLO success was defined as sufficient image quality in split-detector images at the fovea to assess cone quantity. Results: There was excellent agreement between the two observers for assessing OCT artifact severity category (weighted kappa = 0.88). Overall, AOSLO success was 47\%. For subjects with OCT artifact severity category 1, AOSLO success was 65\%; for category 2, 47\%; for category 3, 11\%; and for category 4, 0\%. There was a significant association between OCT artifact severity category and AOSLO success (P = 0.0002). Neither BCVA nor axial length was associated with AOSLO success (P = 0.07 and P = 0.75, respectively). Conclusions: Artifacts in OCT volumes are associated with AOSLO success in ACHM. Subjects with less severe OCT artifacts are more likely to be good candidates for AOSLO imaging, whereas AOSLO was successful in only 7\% of subjects with category 3 or 4 OCT artifacts. These results may be useful in guiding patient selection for AOSLO imaging. Translational Relevance: Using OCT to prescreen patients could be a valuable tool for clinical trials that utilize AOSLO to reduce costs and decrease patient testing burden.",

keywords = "Achromatopsia, Adaptive optics, Inherited retinal disease, Optical coherence tomography",

author = "Litts, \{Katie M.\} and Woertz, \{Erica N.\} and Michalis Georgiou and Patterson, \{Emily J.\} and Lam, \{Byron L.\} and Fishman, \{Gerald A.\} and Pennesi, \{Mark E.\} and Kay, \{Christine N.\} and Hauswirth, \{William W.\} and Michel Michaelides and Joseph Carroll",

year = "2021",

doi = "10.1167/tvst.10.1.11",

language = "English (US)",

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T1 - Optical coherence tomography artifacts are associated with adaptive optics scanning light ophthalmoscopy success in achromatopsia

AU - Litts, Katie M.

AU - Woertz, Erica N.

AU - Georgiou, Michalis

AU - Patterson, Emily J.

AU - Lam, Byron L.

AU - Fishman, Gerald A.

AU - Pennesi, Mark E.

AU - Kay, Christine N.

AU - Hauswirth, William W.

AU - Michaelides, Michel

AU - Carroll, Joseph

PY - 2021

Y1 - 2021

N2 - Purpose: To determine whether artifacts in optical coherence tomography (OCT) images are associated with the success or failure of adaptive optics scanning light ophthalmoscopy (AOSLO) imaging in subjects with achromatopsia (ACHM). Methods: Previously acquired OCT and non-confocal, split-detector AOSLO images from one eye of 66 subjects with genetically confirmed achromatopsia (15 CNGA3 and 51 CNGB3) were reviewed along with best-corrected visual acuity (BCVA) and axial length. OCT artifacts in interpolated vertical volumes from CIRRUS macular cubes were divided into four categories: (1) none or minimal, (2) clear and low frequency, (3) low amplitude and high frequency, and (4) high amplitude and high frequency. Each vertical volume was assessed once by two observers. AOSLO success was defined as sufficient image quality in split-detector images at the fovea to assess cone quantity. Results: There was excellent agreement between the two observers for assessing OCT artifact severity category (weighted kappa = 0.88). Overall, AOSLO success was 47%. For subjects with OCT artifact severity category 1, AOSLO success was 65%; for category 2, 47%; for category 3, 11%; and for category 4, 0%. There was a significant association between OCT artifact severity category and AOSLO success (P = 0.0002). Neither BCVA nor axial length was associated with AOSLO success (P = 0.07 and P = 0.75, respectively). Conclusions: Artifacts in OCT volumes are associated with AOSLO success in ACHM. Subjects with less severe OCT artifacts are more likely to be good candidates for AOSLO imaging, whereas AOSLO was successful in only 7% of subjects with category 3 or 4 OCT artifacts. These results may be useful in guiding patient selection for AOSLO imaging. Translational Relevance: Using OCT to prescreen patients could be a valuable tool for clinical trials that utilize AOSLO to reduce costs and decrease patient testing burden.

AB - Purpose: To determine whether artifacts in optical coherence tomography (OCT) images are associated with the success or failure of adaptive optics scanning light ophthalmoscopy (AOSLO) imaging in subjects with achromatopsia (ACHM). Methods: Previously acquired OCT and non-confocal, split-detector AOSLO images from one eye of 66 subjects with genetically confirmed achromatopsia (15 CNGA3 and 51 CNGB3) were reviewed along with best-corrected visual acuity (BCVA) and axial length. OCT artifacts in interpolated vertical volumes from CIRRUS macular cubes were divided into four categories: (1) none or minimal, (2) clear and low frequency, (3) low amplitude and high frequency, and (4) high amplitude and high frequency. Each vertical volume was assessed once by two observers. AOSLO success was defined as sufficient image quality in split-detector images at the fovea to assess cone quantity. Results: There was excellent agreement between the two observers for assessing OCT artifact severity category (weighted kappa = 0.88). Overall, AOSLO success was 47%. For subjects with OCT artifact severity category 1, AOSLO success was 65%; for category 2, 47%; for category 3, 11%; and for category 4, 0%. There was a significant association between OCT artifact severity category and AOSLO success (P = 0.0002). Neither BCVA nor axial length was associated with AOSLO success (P = 0.07 and P = 0.75, respectively). Conclusions: Artifacts in OCT volumes are associated with AOSLO success in ACHM. Subjects with less severe OCT artifacts are more likely to be good candidates for AOSLO imaging, whereas AOSLO was successful in only 7% of subjects with category 3 or 4 OCT artifacts. These results may be useful in guiding patient selection for AOSLO imaging. Translational Relevance: Using OCT to prescreen patients could be a valuable tool for clinical trials that utilize AOSLO to reduce costs and decrease patient testing burden.

KW - Achromatopsia

KW - Adaptive optics

KW - Inherited retinal disease

KW - Optical coherence tomography

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Optical coherence tomography artifacts are associated with adaptive optics scanning light ophthalmoscopy success in achromatopsia

Abstract

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