@article{c657fc3b536e4ca9afb471a5e40c7226,
title = "Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation",
abstract = "The increased demand on protein folding in the endoplasmic reticulum (ER) during bacterial infection activates the unfolded protein response (UPR). OCTR-1-a G protein-coupled catecholamine receptor expressed in neurons-suppresses innate immunity by downregulating a non-canonical UPR pathway and the p38 MAPK pathway. Here, we show that OCTR-1 also regulates the canonical UPR pathway, which is controlled by XBP-1, at the organismal level. Importantly, XBP-1 is not under OCTR-1 control during development, only at the adult stage. Our results indicate that the nervous system temporally controls the UPR pathway to maintain ER homeostasis during development and immune activation.",
keywords = "ER stress, OCTR-1, innate immunity, nervous system, unfolded protein response",
author = "Jingru Sun and Yiyong Liu and Alejandro Aballay",
year = "2012",
month = sep,
doi = "10.1038/embor.2012.100",
language = "English (US)",
volume = "13",
pages = "855--860",
journal = "EMBO Reports",
issn = "1469-221X",
publisher = "Springer Science and Business Media Deutschland GmbH",
number = "9",
}