Origin of the TEM beta lactamase gene found on plasmids

F. Heffron, R. Sublett, R. W. Hedges, A. Jacob, S. Falkow

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Plasmid mediated resistance to penicillins and cephalosporins is almost universally associated with the elaboration of a β lactamase. Two general classes of drug resistance (R) factor mediated β lactamase are now recognized. The so called TEM type β lactamase (TEM) has a high absolute activity of 60 to 1700 mU of β lactamase per 109 R+ bacteria against benzyl penicillin. Relative to its activity of benzyl penicillin, TEM has high activity on ampicillin and cephaloridine substrates but low activity against isoazolyl penicillins such as oxacillin and methacillin.

Original languageEnglish (US)
Pages (from-to)250-256
Number of pages7
JournalUnknown Journal
Issue number1
StatePublished - 1975
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology


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