Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery

E. A. Neuwelt; K. R. Maravilla; E. P. Frenkel; S. I. Rapaport; S. A. Hill; P. A. Barnett

doi:10.1172/JCI109509

Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery

E. A. Neuwelt, K. R. Maravilla, E. P. Frenkel, S. I. Rapaport, S. A. Hill, P. A. Barnett

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

The present study describes a canine model of transient reversible blood-brain barrier disruption with hyperosmolar mannitol infusion into the internal carotid artery. Studies in this model show that osmotic blood-brain barrier disruption before intracarotid infusion of methotrexate results in markedly elevated (therapeutic) levels of drug in the ipsilateral cerebral hemisphere. Levels in the cerebrospinal fluid correlate poorly and inconsistently with brain levels. Computerized tomograms in this canine model provide a noninvasive monitor of the degree, time-course and localization of osmotic blood-brain barrier disruption.

Original language	English (US)
Pages (from-to)	684-688
Number of pages	5
Journal	Unknown Journal
Volume	64
Issue number	2
DOIs	https://doi.org/10.1172/JCI109509
State	Published - 1979
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Access to Document

10.1172/JCI109509

Cite this

@article{5dcc40c165834a268242c8b0d44fdaad,

title = "Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery",

abstract = "The present study describes a canine model of transient reversible blood-brain barrier disruption with hyperosmolar mannitol infusion into the internal carotid artery. Studies in this model show that osmotic blood-brain barrier disruption before intracarotid infusion of methotrexate results in markedly elevated (therapeutic) levels of drug in the ipsilateral cerebral hemisphere. Levels in the cerebrospinal fluid correlate poorly and inconsistently with brain levels. Computerized tomograms in this canine model provide a noninvasive monitor of the degree, time-course and localization of osmotic blood-brain barrier disruption.",

author = "Neuwelt, {E. A.} and Maravilla, {K. R.} and Frenkel, {E. P.} and Rapaport, {S. I.} and Hill, {S. A.} and Barnett, {P. A.}",

year = "1979",

doi = "10.1172/JCI109509",

language = "English (US)",

volume = "64",

pages = "684--688",

journal = "Unknown Journal",

issn = "0973-3698",

publisher = "Elsevier (Singapore) Pte Ltd",

number = "2",

}

TY - JOUR

T1 - Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery

AU - Neuwelt, E. A.

AU - Maravilla, K. R.

AU - Frenkel, E. P.

AU - Rapaport, S. I.

AU - Hill, S. A.

AU - Barnett, P. A.

PY - 1979

Y1 - 1979

N2 - The present study describes a canine model of transient reversible blood-brain barrier disruption with hyperosmolar mannitol infusion into the internal carotid artery. Studies in this model show that osmotic blood-brain barrier disruption before intracarotid infusion of methotrexate results in markedly elevated (therapeutic) levels of drug in the ipsilateral cerebral hemisphere. Levels in the cerebrospinal fluid correlate poorly and inconsistently with brain levels. Computerized tomograms in this canine model provide a noninvasive monitor of the degree, time-course and localization of osmotic blood-brain barrier disruption.

AB - The present study describes a canine model of transient reversible blood-brain barrier disruption with hyperosmolar mannitol infusion into the internal carotid artery. Studies in this model show that osmotic blood-brain barrier disruption before intracarotid infusion of methotrexate results in markedly elevated (therapeutic) levels of drug in the ipsilateral cerebral hemisphere. Levels in the cerebrospinal fluid correlate poorly and inconsistently with brain levels. Computerized tomograms in this canine model provide a noninvasive monitor of the degree, time-course and localization of osmotic blood-brain barrier disruption.

UR - http://www.scopus.com/inward/record.url?scp=0018776967&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018776967&partnerID=8YFLogxK

U2 - 10.1172/JCI109509

DO - 10.1172/JCI109509

M3 - Article

C2 - 457877

AN - SCOPUS:0018776967

SN - 0973-3698

VL - 64

SP - 684

EP - 688

JO - Unknown Journal

JF - Unknown Journal

IS - 2

ER -

Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this