Overview of mouse assays of ethanol intoxication

John C. Crabbe, Andy J. Cameron, Elizabeth Munn, Mark Bunning, Douglas Wahlsten

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


There are many behavioral assays to assess sensitivity to ethanol intoxication in mice. Most are simple to implement, and are sensitive to a particular dose range of ethanol. Most reflect genetic influences, and each test appears to reflect the contribution of a relatively distinct collection of genes. This genetic heterogeneity implies that no single test can claim to capture the construct "ethanol intoxication" completely. Depending on the test, and when measurements are made, acute functional tolerance to even a single dose of ethanol must be considered as a contributing factor. Whether or not a test is conducted in naïvemice or as part of a test battery can influence sensitivity, and do so in a strain-dependent manner. This unit reviews existing tests and recommends several.

Original languageEnglish (US)
Pages (from-to)9.26.1-9.26.19
JournalCurrent Protocols in Neuroscience
Issue numberSUPPL. 42
StatePublished - 2008
Externally publishedYes


  • Ataxia
  • Ethanol
  • Genetics
  • Inbred strains
  • Intoxication
  • Mouse
  • Test batteries

ASJC Scopus subject areas

  • Neuroscience(all)


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