Ovine Corticotropin-Releasing Hormone Stimulation Test in Normal Children

Judith Levine Ross; Heinrich M. Schulte; William T. Gallucci; Gordon B. Cutler; D. Lynn Loriaux; George P. Chrousos

doi:10.1210/jcem-62-2-390

Ovine Corticotropin-Releasing Hormone Stimulation Test in Normal Children

Judith Levine Ross, Heinrich M. Schulte, William T. Gallucci, Gordon B. Cutler, D. Lynn Loriaux, George P. Chrousos

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

We administered ovine corticotropin-releasing hormone (CRH) as a bolus iv injection (1 µg/kg) to 21 normal boys and girls, aged 6 15 yr. CRH stimulated relea se of immunoreactive ACTH and cortisol in all children. The peak plasma ACTH and cortisol levels after CRH were 15.7 ± 9.4 (SD) pg/ml and 14.3 ± 3.6 µg/dl, respectively, in the girls, and 20.7 ± 9.7 pg/ml and 16.6 ± 3.3 µg/dl, respectively, in the boys. Plasma ACTH and cortisol responsiveness to CRH did hot differ between girls or boys, or between children and adults. Coftisolbinding globulin concentrations in plasma did hot change with age. We conclude that CRH provides a safe means of stimulating the pituitary-adrenal axis in children.

Original language	English (US)
Pages (from-to)	390-392
Number of pages	3
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	62
Issue number	2
DOIs	https://doi.org/10.1210/jcem-62-2-390
State	Published - Feb 1986
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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abstract = "We administered ovine corticotropin-releasing hormone (CRH) as a bolus iv injection (1 µg/kg) to 21 normal boys and girls, aged 6 15 yr. CRH stimulated relea se of immunoreactive ACTH and cortisol in all children. The peak plasma ACTH and cortisol levels after CRH were 15.7 ± 9.4 (SD) pg/ml and 14.3 ± 3.6 µg/dl, respectively, in the girls, and 20.7 ± 9.7 pg/ml and 16.6 ± 3.3 µg/dl, respectively, in the boys. Plasma ACTH and cortisol responsiveness to CRH did hot differ between girls or boys, or between children and adults. Coftisolbinding globulin concentrations in plasma did hot change with age. We conclude that CRH provides a safe means of stimulating the pituitary-adrenal axis in children.",

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AU - Ross, Judith Levine

AU - Schulte, Heinrich M.

AU - Gallucci, William T.

AU - Cutler, Gordon B.

AU - Loriaux, D. Lynn

AU - Chrousos, George P.

PY - 1986/2

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N2 - We administered ovine corticotropin-releasing hormone (CRH) as a bolus iv injection (1 µg/kg) to 21 normal boys and girls, aged 6 15 yr. CRH stimulated relea se of immunoreactive ACTH and cortisol in all children. The peak plasma ACTH and cortisol levels after CRH were 15.7 ± 9.4 (SD) pg/ml and 14.3 ± 3.6 µg/dl, respectively, in the girls, and 20.7 ± 9.7 pg/ml and 16.6 ± 3.3 µg/dl, respectively, in the boys. Plasma ACTH and cortisol responsiveness to CRH did hot differ between girls or boys, or between children and adults. Coftisolbinding globulin concentrations in plasma did hot change with age. We conclude that CRH provides a safe means of stimulating the pituitary-adrenal axis in children.

AB - We administered ovine corticotropin-releasing hormone (CRH) as a bolus iv injection (1 µg/kg) to 21 normal boys and girls, aged 6 15 yr. CRH stimulated relea se of immunoreactive ACTH and cortisol in all children. The peak plasma ACTH and cortisol levels after CRH were 15.7 ± 9.4 (SD) pg/ml and 14.3 ± 3.6 µg/dl, respectively, in the girls, and 20.7 ± 9.7 pg/ml and 16.6 ± 3.3 µg/dl, respectively, in the boys. Plasma ACTH and cortisol responsiveness to CRH did hot differ between girls or boys, or between children and adults. Coftisolbinding globulin concentrations in plasma did hot change with age. We conclude that CRH provides a safe means of stimulating the pituitary-adrenal axis in children.

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Ovine Corticotropin-Releasing Hormone Stimulation Test in Normal Children

Abstract

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