Oxytocin potentiates the ACTH-releasing activity of CRF(41) but not vasopressin

D. M. Gibbs, W. Vale, J. Rivier, S. S.C. Yen

Research output: Contribution to journalArticlepeer-review

107 Scopus citations


The effects of CRF(41), oxytocin (OT), and arginine vasopressin (AVP) on ACTH secretion were studied alone and in combination in an in vitro system of superfused rat hemipituitaries. CRF(41) (10-9M) and AVP (10-8M) alone produced a significant increase in ACTH secretion while OT (10-8M) alone had no effect. However the same concentration of OT markedly potentiated the ACTH response to CRF(41) while having no effect on the ACTH response to AVP. The data support a physiologic role for OT in the regulation of ACTH secretion.

Original languageEnglish (US)
Pages (from-to)2245-2249
Number of pages5
JournalLife Sciences
Issue number23
StatePublished - Jun 4 1984
Externally publishedYes

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology


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