Pancreatic polypeptide (PP)

Dana K. Andersen, F. Charles Brunicardi

Research output: Chapter in Book/Report/Conference proceedingChapter


Pancreatic polypeptide (PP) is secreted from islet cells in the head of the pancreas. Secretion is induced by nutrient ingestion, and is vagally dependent. PP may have a role in satiety and obesity, but its most important role appears to be its regulation of hepatic insulin receptor availability. In pancreatogenic or type 3c diabetes PP deficiency is common, and restoration of PP levels improves glucose metabolism. Pancreatic surgical procedures that spare the PP-rich region of the pancreas have a lower risk of postoperative diabetes. This article summarizes the physiology of PP related to glucose metabolism and highlights new therapeutic opportunities.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Endocrine Diseases
Number of pages12
ISBN (Electronic)9780128122006
ISBN (Print)9780128121993
StatePublished - Jan 1 2018


  • Artificial endocrine pancreas
  • Chronic pancreatitis
  • Glucose metabolism
  • Hepatic insulin receptors
  • Insulin sensitivity
  • Pancreatic polypeptide
  • Pancreatic surgery
  • Pancreatogenic (type 3c) diabetes
  • PP or F cells
  • Y4 receptors

ASJC Scopus subject areas

  • General Medicine


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