Pancreatic polypeptide (PP)

Dana K. Andersen; F. Charles Brunicardi

doi:10.1016/B978-0-12-801238-3.03949-0

Pancreatic polypeptide (PP)

Dana K. Andersen, F. Charles Brunicardi

Gastroenterology and Hepatology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Pancreatic polypeptide (PP) is secreted from islet cells in the head of the pancreas. Secretion is induced by nutrient ingestion, and is vagally dependent. PP may have a role in satiety and obesity, but its most important role appears to be its regulation of hepatic insulin receptor availability. In pancreatogenic or type 3c diabetes PP deficiency is common, and restoration of PP levels improves glucose metabolism. Pancreatic surgical procedures that spare the PP-rich region of the pancreas have a lower risk of postoperative diabetes. This article summarizes the physiology of PP related to glucose metabolism and highlights new therapeutic opportunities.

Original language	English (US)
Title of host publication	Encyclopedia of Endocrine Diseases
Publisher	Elsevier
Pages	534-545
Number of pages	12
ISBN (Electronic)	9780128122006
ISBN (Print)	9780128121993
DOIs	https://doi.org/10.1016/B978-0-12-801238-3.03949-0
State	Published - Jan 1 2018

Keywords

Artificial endocrine pancreas
Chronic pancreatitis
Glucose metabolism
Hepatic insulin receptors
Insulin sensitivity
Pancreatic polypeptide
Pancreatic surgery
Pancreatogenic (type 3c) diabetes
PP or F cells
Y4 receptors

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-12-801238-3.03949-0

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title = "Pancreatic polypeptide (PP)",

abstract = "Pancreatic polypeptide (PP) is secreted from islet cells in the head of the pancreas. Secretion is induced by nutrient ingestion, and is vagally dependent. PP may have a role in satiety and obesity, but its most important role appears to be its regulation of hepatic insulin receptor availability. In pancreatogenic or type 3c diabetes PP deficiency is common, and restoration of PP levels improves glucose metabolism. Pancreatic surgical procedures that spare the PP-rich region of the pancreas have a lower risk of postoperative diabetes. This article summarizes the physiology of PP related to glucose metabolism and highlights new therapeutic opportunities.",

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AB - Pancreatic polypeptide (PP) is secreted from islet cells in the head of the pancreas. Secretion is induced by nutrient ingestion, and is vagally dependent. PP may have a role in satiety and obesity, but its most important role appears to be its regulation of hepatic insulin receptor availability. In pancreatogenic or type 3c diabetes PP deficiency is common, and restoration of PP levels improves glucose metabolism. Pancreatic surgical procedures that spare the PP-rich region of the pancreas have a lower risk of postoperative diabetes. This article summarizes the physiology of PP related to glucose metabolism and highlights new therapeutic opportunities.

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KW - Pancreatogenic (type 3c) diabetes

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KW - Y4 receptors

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PB - Elsevier

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Pancreatic polypeptide (PP)

Abstract

Keywords

ASJC Scopus subject areas

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