Panic Attacks and Phobias

Peter H. Keefe, W. Stewart Agras, Isaac Marks, Richard R. Neubig, Gregory J. Magarian, David A. Nardone, Douglas A. Hedlund, David V. Sheehan

Research output: Contribution to journalLetterpeer-review

1 Scopus citations


To the Editor: Sheehan (July 15 issue1) cites double-blind, placebo-controlled studies as demonstrating the effectiveness of monoamine oxidase inhibitors and tricyclic antidepressants in treating spontaneous panic attacks.2 3 4 However, in all these studies, imipramine was given in a setting of in vivo exposure, supportive psychotherapy combined with instructions on exposure,2,3 or other, unspecified psychotherapy.4 In patients with agoraphobia who were treated by Zitrin et al.2,3 imipramine seemed to have an early effect on panic but was associated with a higher relapse rale than placebo at six months and one year (30 per cent for imipramine vs. 14 per cent.

Original languageEnglish (US)
Pages (from-to)341-343
Number of pages3
JournalNew England Journal of Medicine
Issue number6
StatePublished - Feb 10 1983
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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