Parabrachial Complex: A Hub for Pain and Aversion

Michael C. Chiang, Anna Bowen, Lindsey A. Schier, Domenico Tupone, Olivia Uddin, Mary M. Heinricher

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


The parabrachial nucleus (PBN) has long been recognized as a sensory relay receiving an array of interoceptive and exteroceptive inputs relevant to taste and ingestive behavior, pain, and multiple aspects of autonomic control, including respiration, blood pressure, water balance, and thermoregulation. Outputs are known to be similarly widespread and complex. How sensory information is handled in PBN and used to inform different outputs to maintain homeostasis and promote survival is only now being elucidated. With a focus on taste and ingestive behaviors, pain, and thermoregulation, this review is intended to provide a context for analysis of PBN circuits involved in aversion and avoidance, and consider how information of various modalities, interoceptive and exteroceptive, is processed within PBN and transmitted to distinct targets to signal challenge, and to engage appropriate behavioral and physiological responses to maintain homeostasis.

Original languageEnglish (US)
Pages (from-to)8225-8230
Number of pages6
JournalThe Journal of neuroscience : the official journal of the Society for Neuroscience
Issue number42
StatePublished - Oct 16 2019


  • alarm
  • brainstem
  • defense
  • nociception
  • taste
  • thermoregulation

ASJC Scopus subject areas

  • Neuroscience(all)


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