Paradoxical roles of the immune system during cancer development

Karin E. De Visser; Alexandra Eichten; Lisa M. Coussens

doi:10.1038/nrc1782

Paradoxical roles of the immune system during cancer development

Karin E. De Visser, Alexandra Eichten, Lisa M. Coussens

Research output: Contribution to journal › Review article › peer-review

1926 Scopus citations

Abstract

The main function of the mammalian immune system is to monitor tissue homeostasis, to protect against invading or infectious pathogens and to eliminate damaged cells. Therefore, it is surprising that cancer occurs with such a high frequency in humans. Recent insights that have been gained from clinical studies and experimental mouse models of carcinogenesis expand our understanding of the complex relationship between immune cells and developing tumours. Here, we examine the paradoxical role of adaptive and innate leukocytes as crucial regulators of cancer development and highlight recent insights that have been gained by manipulating immune responses in mouse models of de novo and spontaneous tumorigenesis.

Original language	English (US)
Pages (from-to)	24-37
Number of pages	14
Journal	Nature Reviews Cancer
Volume	6
Issue number	1
DOIs	https://doi.org/10.1038/nrc1782
State	Published - Jan 2006
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Paradoxical roles of the immune system during cancer development",

abstract = "The main function of the mammalian immune system is to monitor tissue homeostasis, to protect against invading or infectious pathogens and to eliminate damaged cells. Therefore, it is surprising that cancer occurs with such a high frequency in humans. Recent insights that have been gained from clinical studies and experimental mouse models of carcinogenesis expand our understanding of the complex relationship between immune cells and developing tumours. Here, we examine the paradoxical role of adaptive and innate leukocytes as crucial regulators of cancer development and highlight recent insights that have been gained by manipulating immune responses in mouse models of de novo and spontaneous tumorigenesis.",

author = "{De Visser}, {Karin E.} and Alexandra Eichten and Coussens, {Lisa M.}",

note = "Funding Information: We acknowledge all the scientists who made contributions to the areas of research that are reviewed here but were not cited owing to space constraints. We are grateful to T. Tlsty and the University of California, San Francisco, Breast and Prostate Specialized Programs of Research Excellence for providing human tissue sections. The authors were supported by grants from the Dutch Cancer Society (K.E.d.V.), the Serono Foundation for Advancement of Medical Science (A.E.), the National Institutes of Health, the Sandler Program in Basic Sciences, the National Technology Center for Networks and Pathways and a Department of Defense Breast Cancer Center of Excellence grant.",

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AU - Eichten, Alexandra

AU - Coussens, Lisa M.

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Paradoxical roles of the immune system during cancer development

Abstract

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