Partnerships for Drug Repositioning: Lessons from the CTSA Pharmaceutical Assets Portal

Kate Marusina; Dean J. Welsch; Lynn Rose; Doug Brock; Nathan Bahr; Aaron M. Cohen; Rafael A. Gacel-Sinclair; Pakou Vang; Peter G. Ruminski; Bruce E. Bloom; Pamela Nagasawa; Betty P. Guo

doi:10.1002/9781118778166.ch9

Partnerships for Drug Repositioning: Lessons from the CTSA Pharmaceutical Assets Portal

Kate Marusina, Dean J. Welsch, Lynn Rose, Doug Brock, Nathan Bahr, Aaron M. Cohen, Rafael A. Gacel-Sinclair, Pakou Vang, Peter G. Ruminski, Bruce E. Bloom, Pamela Nagasawa, Betty P. Guo

Medical Informatics and Clinical Epidemiology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Drug repositioning, or finding new uses for existing compounds, is a novel approach to drug development, with great potential for reducing the time and cost of bringing a new treatment to the market. The mission of the CTSA Pharmaceutical Assets Portal has been to facilitate collaborations between industry and academic investigators for discovery of new indications for compounds that are no longer being actively developed by pharmaceutical companies. While the ultimate goal of creating a shared repository accessible to the academic community remains to be achieved, to date, the Pharma Portal has created an infrastructure that includes a national database of principal investigators with their respective biological models and delivery systems; a foci-of-expertise collaboration tool; a facility to house and maintain a compound repository; and a funding partner for repositioning studies. In summary, the Pharma Portal has created a strategy and a mechanism to support future opportunities for public-private partnerships in drug repositioning.

Original language	English (US)
Title of host publication	Collaborative Innovation in Drug Discovery
Subtitle of host publication	Strategies for Public and Private Partnerships
Publisher	Wiley-Blackwell
Pages	115-133
Number of pages	19
ISBN (Electronic)	9781118778166
ISBN (Print)	9780470917374
DOIs	https://doi.org/10.1002/9781118778166.ch9
State	Published - Apr 14 2014

Keywords

CTSA
Drug discovery
Pharmaceutical
Repositioning
Repurposing

ASJC Scopus subject areas

Medicine(all)
Pharmacology, Toxicology and Pharmaceutics(all)
Chemistry(all)
Engineering(all)
Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1002/9781118778166.ch9

Cite this

Marusina, K., Welsch, D. J., Rose, L., Brock, D., Bahr, N., Cohen, A. M., Gacel-Sinclair, R. A., Vang, P., Ruminski, P. G., Bloom, B. E., Nagasawa, P., & Guo, B. P. (2014). Partnerships for Drug Repositioning: Lessons from the CTSA Pharmaceutical Assets Portal. In Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships (pp. 115-133). Wiley-Blackwell. https://doi.org/10.1002/9781118778166.ch9

Marusina, K, Welsch, DJ, Rose, L, Brock, D, Bahr, N, Cohen, AM, Gacel-Sinclair, RA, Vang, P, Ruminski, PG, Bloom, BE, Nagasawa, P & Guo, BP 2014, Partnerships for Drug Repositioning: Lessons from the CTSA Pharmaceutical Assets Portal. in Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships. Wiley-Blackwell, pp. 115-133. https://doi.org/10.1002/9781118778166.ch9

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abstract = "Drug repositioning, or finding new uses for existing compounds, is a novel approach to drug development, with great potential for reducing the time and cost of bringing a new treatment to the market. The mission of the CTSA Pharmaceutical Assets Portal has been to facilitate collaborations between industry and academic investigators for discovery of new indications for compounds that are no longer being actively developed by pharmaceutical companies. While the ultimate goal of creating a shared repository accessible to the academic community remains to be achieved, to date, the Pharma Portal has created an infrastructure that includes a national database of principal investigators with their respective biological models and delivery systems; a foci-of-expertise collaboration tool; a facility to house and maintain a compound repository; and a funding partner for repositioning studies. In summary, the Pharma Portal has created a strategy and a mechanism to support future opportunities for public-private partnerships in drug repositioning.",

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AB - Drug repositioning, or finding new uses for existing compounds, is a novel approach to drug development, with great potential for reducing the time and cost of bringing a new treatment to the market. The mission of the CTSA Pharmaceutical Assets Portal has been to facilitate collaborations between industry and academic investigators for discovery of new indications for compounds that are no longer being actively developed by pharmaceutical companies. While the ultimate goal of creating a shared repository accessible to the academic community remains to be achieved, to date, the Pharma Portal has created an infrastructure that includes a national database of principal investigators with their respective biological models and delivery systems; a foci-of-expertise collaboration tool; a facility to house and maintain a compound repository; and a funding partner for repositioning studies. In summary, the Pharma Portal has created a strategy and a mechanism to support future opportunities for public-private partnerships in drug repositioning.

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Partnerships for Drug Repositioning: Lessons from the CTSA Pharmaceutical Assets Portal

Abstract

Keywords

ASJC Scopus subject areas

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