Pathogenesis of precocious puberty in hypothalamic hamartoma

Heike Jung, Sergio R. Ojeda

    Research output: Contribution to journalArticlepeer-review

    42 Scopus citations


    Astroglial-derived factors, as transforming growth factor (TGF)α and TGFβ, act in the hypothalamus to activate luteinizing hormone-releasing hormone (LHRH) secretion. Hypothalamic hamartomas (HHs) contain normal nervous tissue in a heterotopic location. When symptomatic, they cause precocious puberty and/or characteristic gelastic seizures. Thus far, the pathogenesis of these alterations remains unknown. By examining two HHs associated with sexual precocity, we found that they contained astroglial cells expressing TGFα, but no LHRH neurons. In a third patient with HH, only epilepsy was present, but precocious puberty developed shortly after surgery, probably as a consequence of a surgery-induced lesion. These results imply that some HHs induce sexual precocity by activating endogenous LHRH secretion via astroglial-derived factors.

    Original languageEnglish (US)
    Pages (from-to)31-34
    Number of pages4
    JournalHormone Research
    Issue numberSUPPL. 2
    StatePublished - Jun 26 2002


    • Hamartoma
    • Hypothalamus
    • Pathogenesis
    • Precocious puberty

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology


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