Abstract
BACKGROUND: Pharmaceutical industry financial support of physicians, physician practices, and academic departments involved in multicenter industry-sponsored clinical trials of novel therapeutic agents is a relatively new and infrequently acknowledged source of potential physician conflict of interest. Detailed disclosure of these relationships to study participants is not uniformly a part of informed consent and documentation practices. OBJECTIVE: To understand attitudes of patients with multiple sclerosis concerning disclosure of potential physician-industry conflicts of interest created by clinical trials and how such disclosures may influence study participation METHODS: An anonymous online instrument was developed. RESULTS: 597 people with multiple sclerosis participated in the study. The study found that detailed disclosure of conflicts of interest is important to potential participants in industry-sponsored clinical trials for multiple sclerosis therapies and that the presence of these conflicts of interest may influence patients' decisions to participate in these studies. CONCLUSIONS: Findings from this study support a call for uniform guidelines regarding disclosure of physician-industry relationships to prospective research participants for industry-sponsored clinical trials.
Original language | English (US) |
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Title of host publication | Getting to Good |
Subtitle of host publication | Research Integrity in the Biomedical Sciences |
Publisher | Springer International Publishing |
Pages | 498-506 |
Number of pages | 9 |
ISBN (Electronic) | 9783319513584 |
ISBN (Print) | 9783319513577 |
DOIs | |
State | Published - Jul 23 2018 |
Keywords
- Clinical trials
- Conflict of interest
- Industry-sponsored clinical trials
- Multiple sclerosis
- Professional conduct and ethics
ASJC Scopus subject areas
- General Medicine