Patient perspectives on physician conflict of interest in industry-sponsored clinical trials for multiple sclerosis therapeutics

Andrew J. Solomon, Eran P. Klein, John R. Corboy, James L. Bernat

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


BACKGROUND: Pharmaceutical industry financial support of physicians, physician practices, and academic departments involved in multicenter industry-sponsored clinical trials of novel therapeutic agents is a relatively new and infrequently acknowledged source of potential physician conflict of interest. Detailed disclosure of these relationships to study participants is not uniformly a part of informed consent and documentation practices. OBJECTIVE: To understand attitudes of patients with multiple sclerosis concerning disclosure of potential physician-industry conflicts of interest created by clinical trials and how such disclosures may influence study participation METHODS: An anonymous online instrument was developed. RESULTS: 597 people with multiple sclerosis participated in the study. The study found that detailed disclosure of conflicts of interest is important to potential participants in industry-sponsored clinical trials for multiple sclerosis therapies and that the presence of these conflicts of interest may influence patients' decisions to participate in these studies. CONCLUSIONS: Findings from this study support a call for uniform guidelines regarding disclosure of physician-industry relationships to prospective research participants for industry-sponsored clinical trials.

Original languageEnglish (US)
Title of host publicationGetting to Good
Subtitle of host publicationResearch Integrity in the Biomedical Sciences
PublisherSpringer International Publishing
Number of pages9
ISBN (Electronic)9783319513584
ISBN (Print)9783319513577
StatePublished - Jul 23 2018


  • Clinical trials
  • Conflict of interest
  • Industry-sponsored clinical trials
  • Multiple sclerosis
  • Professional conduct and ethics

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Patient perspectives on physician conflict of interest in industry-sponsored clinical trials for multiple sclerosis therapeutics'. Together they form a unique fingerprint.

Cite this