TY - JOUR
T1 - Patient-reported outcomes and joint status across subgroups of US adults with hemophilia with varying characteristics
T2 - Results from the Pain, Functional Impairment, and Quality of Life (P-FiQ) study
AU - Batt, Katharine
AU - Boggio, Lisa
AU - Neff, Anne
AU - Buckner, Tyler W.
AU - Wang, Michael
AU - Quon, Doris
AU - Witkop, Michelle
AU - Recht, Michael
AU - Kessler, Craig
AU - Iyer, Neeraj N.
AU - Cooper, David L.
N1 - Publisher Copyright:
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2018/4
Y1 - 2018/4
N2 - Introduction: Pain and functional impairment associated with joint disease are major problems for people with hemophilia, and impact on health-related quality of life (HRQoL) may vary across groups defined by demographic and treatment-related characteristics. Objective: To evaluate differences in overall HRQoL, pain, function, and joint status between P-FiQ study subgroups. Methods: Adult males with hemophilia and a history of joint pain/bleeding completed a pain history and the patient-reported outcome instruments EQ-5D-5L, Brief Pain Inventory v2 Short Form (BPI), International Physical Activity Questionnaire (IPAQ), and Hemophilia Activities List (HAL); optionally, joint status was assessed (Hemophilia Joint Health Score v2.1 [HJHS]). Scores were analyzed between subgroups across sets of participant characteristics. Results: A total of 381 adult males with hemophilia were enrolled, with median age of 34 years. Worse scores on EQ-5D-5L index, BPI pain severity/interference, HAL overall score, and HJHS were generally associated with being college educated, unemployment, self-reporting both acute and chronic pain, and self-reporting anxiety/depression. Conclusions: Measures of joint status and HRQoL were consistently lower in participants who had higher educational levels, were unemployed, self-reported having both acute and chronic pain, and self-reported having anxiety/depression. A greater understanding of the association of these factors with disease outcomes may improve individualized patient management.
AB - Introduction: Pain and functional impairment associated with joint disease are major problems for people with hemophilia, and impact on health-related quality of life (HRQoL) may vary across groups defined by demographic and treatment-related characteristics. Objective: To evaluate differences in overall HRQoL, pain, function, and joint status between P-FiQ study subgroups. Methods: Adult males with hemophilia and a history of joint pain/bleeding completed a pain history and the patient-reported outcome instruments EQ-5D-5L, Brief Pain Inventory v2 Short Form (BPI), International Physical Activity Questionnaire (IPAQ), and Hemophilia Activities List (HAL); optionally, joint status was assessed (Hemophilia Joint Health Score v2.1 [HJHS]). Scores were analyzed between subgroups across sets of participant characteristics. Results: A total of 381 adult males with hemophilia were enrolled, with median age of 34 years. Worse scores on EQ-5D-5L index, BPI pain severity/interference, HAL overall score, and HJHS were generally associated with being college educated, unemployment, self-reporting both acute and chronic pain, and self-reporting anxiety/depression. Conclusions: Measures of joint status and HRQoL were consistently lower in participants who had higher educational levels, were unemployed, self-reported having both acute and chronic pain, and self-reported having anxiety/depression. A greater understanding of the association of these factors with disease outcomes may improve individualized patient management.
KW - coagulation disorders
KW - quality of life
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U2 - 10.1111/ejh.13028
DO - 10.1111/ejh.13028
M3 - Article
C2 - 29498783
AN - SCOPUS:85042711005
SN - 0902-4441
VL - 100
SP - 14
EP - 24
JO - European Journal of Haematology
JF - European Journal of Haematology
ER -