Performance of emergency department screening criteria for an early ecg to identify ST-segment elevation myocardial infarction

Maame Yaa A.B. Yiadom, Christopher W. Baugh, Conor M. McWade, Xulei Liu, Kyoung Jun Song, Brian W. Patterson, Cathy A. Jenkins, Mary Tanski, Angela M. Mills, Gilberto Salazar, Thomas J. Wang, Robert S. Dittus, Dandan Liu, Alan B. Storrow

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Background-Timely diagnosis of ST-segment elevation myocardial infarction (STEMI) in the emergency department (ED) is made solely by ECG. Obtaining this test within 10 minutes of ED arrival is critical to achieving the best outcomes. We investigated variability in the timely identification of STEMI across institutions and whether performance variation was associated with the ED characteristics, the comprehensiveness of screening criteria, and the STEMI screening processes. Methods and Results-We examined STEMI screening performance in 7 EDs, with the missed case rate (MCR) as our primary end point. The MCR is the proportion of primarily screened ED patients diagnosed with STEMI who did not receive an ECG within 15 minutes of ED arrival. STEMI was defined by hospital discharge diagnosis. Relationships between the MCR and ED characteristics, screening criteria, and STEMI screening processes were assessed, along with differences in door-to-ECG times for captured versus missed patients. The overall MCR for all 7 EDs was 12.8%. The lowest and highest MCRs were 3.4% and 32.6%, respectively. The mean difference in door-to-ECG times for captured and missed patients was 31 minutes, with a range of 14 to 80 minutes of additional myocardial ischemia time for missed cases. The prevalence of primarily screened ED STEMIs was 0.09%. EDs with the greatest informedness (sensitivity+specificity-1) demonstrated superior performance across all other screening measures. Conclusions-The 29.2% difference in MCRs between the highest and lowest performing EDs demonstrates room for improving timely STEMI identification among primarily screened ED patients. The MCR and informedness can be used to compare screening across EDs and to understand variable performance.

Original languageEnglish (US)
Article numbere003528
JournalJournal of the American Heart Association
Issue number3
StatePublished - 2017


  • Emergency department
  • False-negative rate
  • Informedness
  • Missed case rate
  • ST-segment elevation myocardial infarction
  • Screening
  • Timely care

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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