@inbook{79c83f6e5d434b22a6c96ac92b09105a,
title = "Peri-adolescent exposure to (meth)amphetamine in animal models",
abstract = "Experimentation with psychoactive drugs is often initiated in the peri-adolescent period, but knowledge of differences in the outcomes of peri-adolescent- vs adult-initiated exposure is incomplete. We consider the existing animal research in this area for (meth)amphetamines. Established for a number of phenotypes, is lower sensitivity of peri-adolescents than adults to acute effects of (meth)amphetamines, including neurotoxic effects of binge-level exposure. More variable are data for long-term consequences of peri-adolescent exposure on motivational and cognitive traits. Moreover, investigations often exclude an adult-initiated exposure group critical for answering questions about outcomes unique to peri-adolescent initiation. Despite this, it is clear from the animal research that (meth)amphetamine exposure during the peri-adolescent period, whether self- or other-administered, impacts brain motivational circuitry and cognitive function, and alters adult sensitivity to other drugs and natural rewards. Such consequences occurring in humans have the potential to predispose toward unfortunate and potentially disastrous family, social and livelihood outcomes.",
keywords = "Addiction, Amphetamine, Cognition, Methamphetamine, Motivation, Neurotoxicity, Reward, Social behavior",
author = "Phillips, {T. J.} and Aldrich, {S. J.}",
note = "Funding Information: Funding was provided by NIDA U01DA041579 (T.J.P.), NIDA R01DA046081 (T.J.P.), Department of Veterans Affairs Merit Review Grant I01BX002106 (T.J.P.), and the VA Research Career Scientist Program (T.J.P.) during the writing of the manuscript. The contents of this article do not represent the views of the U.S. Department of Veterans Affairs or the United States government. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",
year = "2022",
month = jan,
doi = "10.1016/bs.irn.2021.06.011",
language = "English (US)",
isbn = "9780323992602",
series = "International Review of Neurobiology",
publisher = "Academic Press Inc.",
pages = "1--51",
editor = "Bell, {Richard L.} and Shafiqur Rahman",
booktitle = "Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS Part II",
}