Peri-adolescent exposure to (meth)amphetamine in animal models

T. J. Phillips, S. J. Aldrich

Research output: Chapter in Book/Report/Conference proceedingChapter


Experimentation with psychoactive drugs is often initiated in the peri-adolescent period, but knowledge of differences in the outcomes of peri-adolescent- vs adult-initiated exposure is incomplete. We consider the existing animal research in this area for (meth)amphetamines. Established for a number of phenotypes, is lower sensitivity of peri-adolescents than adults to acute effects of (meth)amphetamines, including neurotoxic effects of binge-level exposure. More variable are data for long-term consequences of peri-adolescent exposure on motivational and cognitive traits. Moreover, investigations often exclude an adult-initiated exposure group critical for answering questions about outcomes unique to peri-adolescent initiation. Despite this, it is clear from the animal research that (meth)amphetamine exposure during the peri-adolescent period, whether self- or other-administered, impacts brain motivational circuitry and cognitive function, and alters adult sensitivity to other drugs and natural rewards. Such consequences occurring in humans have the potential to predispose toward unfortunate and potentially disastrous family, social and livelihood outcomes.

Original languageEnglish (US)
Title of host publicationEffects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS Part II
EditorsRichard L. Bell, Shafiqur Rahman
PublisherAcademic Press Inc.
Number of pages51
ISBN (Print)9780323992602
StatePublished - Jan 2022

Publication series

NameInternational Review of Neurobiology
ISSN (Print)0074-7742
ISSN (Electronic)2162-5514


  • Addiction
  • Amphetamine
  • Cognition
  • Methamphetamine
  • Motivation
  • Neurotoxicity
  • Reward
  • Social behavior

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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