TY - JOUR
T1 - Peripheral immune factors are elevated in women with current or recent alcohol dependence and associated with altered mood and memory
AU - Wilhelm, Clare J.
AU - Fuller, Bret E.
AU - Huckans, Marilyn
AU - Loftis, Jennifer M.
N1 - Publisher Copyright:
© 2017
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Background The adverse effects of alcohol on brain function result, in part, from inflammatory processes. The sex-specific neuropsychiatric consequences and inflammatory status of active alcohol dependence and early remission from dependence have not been investigated. Methods Neuropsychiatric symptoms, inflammatory factors, and liver enzymes were compared in a prospective cohort study of adults with (n = 51) or without (n = 31) a current or recent history of alcohol dependence. Results Neuropsychiatric profiles were similar in adults with current or recent alcohol dependence regardless of sex. In male and female participants measures of depression (female p < 0.05, male p < 0.001), anxiety (female p < 0.001, male p < 0.001), and memory complaints (female p < 0.001, male p < 0.05) were elevated, relative to non-dependent controls. Significant sex × alcohol dependence history interactions were observed for plasma levels of tissue inhibitor of metalloproteinase 1 (TIMP-1) and brain derived neurotrophic factor (BDNF), with women in the alcohol dependent group exhibiting increased levels of both analytes (p < 0.05) relative to controls. Positive correlations between TIMP-1 levels and measures of depression (r2 = 0.35, p < 0.01), anxiety (r2 = 0.24, p < 0.05) and memory complaints (r2 = 0.44, p < 0.01) were found in female, but not male, participants. Conclusions Though neuropsychiatric profiles were similar for men and women with current or recent alcohol dependence, plasma factors associated with increases in depression, anxiety, and memory impairment differed and support the need to tailor treatments based on sex.
AB - Background The adverse effects of alcohol on brain function result, in part, from inflammatory processes. The sex-specific neuropsychiatric consequences and inflammatory status of active alcohol dependence and early remission from dependence have not been investigated. Methods Neuropsychiatric symptoms, inflammatory factors, and liver enzymes were compared in a prospective cohort study of adults with (n = 51) or without (n = 31) a current or recent history of alcohol dependence. Results Neuropsychiatric profiles were similar in adults with current or recent alcohol dependence regardless of sex. In male and female participants measures of depression (female p < 0.05, male p < 0.001), anxiety (female p < 0.001, male p < 0.001), and memory complaints (female p < 0.001, male p < 0.05) were elevated, relative to non-dependent controls. Significant sex × alcohol dependence history interactions were observed for plasma levels of tissue inhibitor of metalloproteinase 1 (TIMP-1) and brain derived neurotrophic factor (BDNF), with women in the alcohol dependent group exhibiting increased levels of both analytes (p < 0.05) relative to controls. Positive correlations between TIMP-1 levels and measures of depression (r2 = 0.35, p < 0.01), anxiety (r2 = 0.24, p < 0.05) and memory complaints (r2 = 0.44, p < 0.01) were found in female, but not male, participants. Conclusions Though neuropsychiatric profiles were similar for men and women with current or recent alcohol dependence, plasma factors associated with increases in depression, anxiety, and memory impairment differed and support the need to tailor treatments based on sex.
KW - Alcohol use disorder
KW - Anxiety
KW - Cognitive impairment
KW - Depression
KW - Inflammation
KW - Sex differences
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U2 - 10.1016/j.drugalcdep.2017.02.023
DO - 10.1016/j.drugalcdep.2017.02.023
M3 - Article
C2 - 28525828
AN - SCOPUS:85019431934
SN - 0376-8716
VL - 176
SP - 71
EP - 78
JO - Drug and Alcohol Dependence
JF - Drug and Alcohol Dependence
ER -