Pertussis toxin blocks the dipsogenic actions of carbachol, but does not block the dipsogenic and pressor actions of angiotensin II

R. C. Speth; K. L. Grove

doi:10.1016/0167-0115(91)90040-N

Pertussis toxin blocks the dipsogenic actions of carbachol, but does not block the dipsogenic and pressor actions of angiotensin II

R. C. Speth
, K. L. Grove

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Rats were tested for dipsogenic and pressor responses to intracerebroventricularly (icv) administered Ang II and for dipsogenic responses to icv administered carbachol in the absence and presence of pertussis toxin, also administered icv. Pertussis toxin did not inhibit the pressor or dipsogenic responses to Ang II, but did inhibit the dipsogenic responses to carbachol. This suggests that the pressor and dipsogenic responses to Ang II in the brain are not mediated by a pertussis toxin-sensitive G protein, but that the muscarinic cholinergic dipsogenic response is mediated by a pertussis toxin-sensitive G protein.

Original language	English (US)
Pages (from-to)	121-128
Number of pages	8
Journal	Regulatory Peptides
Volume	32
Issue number	2
DOIs	https://doi.org/10.1016/0167-0115(91)90040-N
State	Published - Feb 1 1991
Externally published	Yes

Funding

The authors thank Renee Andrea and Machele Schuster for their excellent technical assistance. Supported by National Institutes of Health (NS21305).

Funders	Funder number
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health
National Institute of Neurological Disorders and Stroke	R01NS021305

Keywords

Angiotensin II receptor
Blood pressure
Dipsogenesis
GTP binding protein
Muscarinic cholinergic receptor
Pertussis toxin

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Clinical Biochemistry
Cellular and Molecular Neuroscience

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10.1016/0167-0115(91)90040-N

Cite this

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title = "Pertussis toxin blocks the dipsogenic actions of carbachol, but does not block the dipsogenic and pressor actions of angiotensin II",

abstract = "Rats were tested for dipsogenic and pressor responses to intracerebroventricularly (icv) administered Ang II and for dipsogenic responses to icv administered carbachol in the absence and presence of pertussis toxin, also administered icv. Pertussis toxin did not inhibit the pressor or dipsogenic responses to Ang II, but did inhibit the dipsogenic responses to carbachol. This suggests that the pressor and dipsogenic responses to Ang II in the brain are not mediated by a pertussis toxin-sensitive G protein, but that the muscarinic cholinergic dipsogenic response is mediated by a pertussis toxin-sensitive G protein.",

keywords = "Angiotensin II receptor, Blood pressure, Dipsogenesis, GTP binding protein, Muscarinic cholinergic receptor, Pertussis toxin",

author = "Speth, \{R. C.\} and Grove, \{K. L.\}",

note = "Funding Information: The authors thank Renee Andrea and Machele Schuster for their excellent technical assistance. Supported by National Institutes of Health (NS21305).",

year = "1991",

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doi = "10.1016/0167-0115(91)90040-N",

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T1 - Pertussis toxin blocks the dipsogenic actions of carbachol, but does not block the dipsogenic and pressor actions of angiotensin II

AU - Speth, R. C.

AU - Grove, K. L.

N1 - Funding Information: The authors thank Renee Andrea and Machele Schuster for their excellent technical assistance. Supported by National Institutes of Health (NS21305).

PY - 1991/2/1

Y1 - 1991/2/1

N2 - Rats were tested for dipsogenic and pressor responses to intracerebroventricularly (icv) administered Ang II and for dipsogenic responses to icv administered carbachol in the absence and presence of pertussis toxin, also administered icv. Pertussis toxin did not inhibit the pressor or dipsogenic responses to Ang II, but did inhibit the dipsogenic responses to carbachol. This suggests that the pressor and dipsogenic responses to Ang II in the brain are not mediated by a pertussis toxin-sensitive G protein, but that the muscarinic cholinergic dipsogenic response is mediated by a pertussis toxin-sensitive G protein.

AB - Rats were tested for dipsogenic and pressor responses to intracerebroventricularly (icv) administered Ang II and for dipsogenic responses to icv administered carbachol in the absence and presence of pertussis toxin, also administered icv. Pertussis toxin did not inhibit the pressor or dipsogenic responses to Ang II, but did inhibit the dipsogenic responses to carbachol. This suggests that the pressor and dipsogenic responses to Ang II in the brain are not mediated by a pertussis toxin-sensitive G protein, but that the muscarinic cholinergic dipsogenic response is mediated by a pertussis toxin-sensitive G protein.

KW - Angiotensin II receptor

KW - Blood pressure

KW - Dipsogenesis

KW - GTP binding protein

KW - Muscarinic cholinergic receptor

KW - Pertussis toxin

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Pertussis toxin blocks the dipsogenic actions of carbachol, but does not block the dipsogenic and pressor actions of angiotensin II

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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