TY - JOUR
T1 - Phage pattern-specific oxacillin-resistant and borderline oxacillin-resistant Staphylococcus aureus in U.S. hospitals
T2 - Epidemiological significance
AU - Zierdt, C. H.
AU - Hosein, I. K.
AU - Shively, R.
AU - MacLowry, J. D.
PY - 1992
Y1 - 1992
N2 - For a 13-year period (1978 through 1990), oxacillin-resistant (MIC, >4 μg/ml) Staphylococcus aureus (ORSA) strains were collected from Clinical Center (National Institutes of Health) patients and patients from five other U.S. hospitals. From Clinical Center patients, 251 of 253 isolates (99%) were bacteriophage typed as phage group III. Five other hospitals contributed 203 ORSA strains, of which 188 (93%) were group III. The group III ORSA strains predominantly included a characteristic core pattern of phages, 7/47/53/54/75/77. For the low-level (borderline) oxacillin-resistant strains (MIC, 2 to 4 μg/ml), amoxicillin-clavulanic acid combination (Augmentin) testing disclosed 62 hyper-β-lactamase producers, of which 59 (95%) were of a separate, distinct S. aureus strain, with the phage pattern 92/94/96/292/D-11 (group V). Thus, ORSA and hyper-β-lactamase producing S. aureus are distinct epidemic strains.
AB - For a 13-year period (1978 through 1990), oxacillin-resistant (MIC, >4 μg/ml) Staphylococcus aureus (ORSA) strains were collected from Clinical Center (National Institutes of Health) patients and patients from five other U.S. hospitals. From Clinical Center patients, 251 of 253 isolates (99%) were bacteriophage typed as phage group III. Five other hospitals contributed 203 ORSA strains, of which 188 (93%) were group III. The group III ORSA strains predominantly included a characteristic core pattern of phages, 7/47/53/54/75/77. For the low-level (borderline) oxacillin-resistant strains (MIC, 2 to 4 μg/ml), amoxicillin-clavulanic acid combination (Augmentin) testing disclosed 62 hyper-β-lactamase producers, of which 59 (95%) were of a separate, distinct S. aureus strain, with the phage pattern 92/94/96/292/D-11 (group V). Thus, ORSA and hyper-β-lactamase producing S. aureus are distinct epidemic strains.
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U2 - 10.1128/jcm.30.1.252-254.1992
DO - 10.1128/jcm.30.1.252-254.1992
M3 - Comment/debate
C2 - 1734064
AN - SCOPUS:0026556572
SN - 0095-1137
VL - 30
SP - 252
EP - 254
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 1
ER -