TY - JOUR
T1 - Physiopathology of the cochlear microcirculation
AU - Shi, Xiaorui
N1 - Funding Information:
This work was supported by National Institutes of Health grants R03-DC008888 (X.S.) , DC008888S1 (X.S.) , R01-NIDCD DC010844 (X.S) , P30-DC005983.DC 00105 and R01 DC00105 .
PY - 2011/12
Y1 - 2011/12
N2 - Normal blood supply to the cochlea is critically important for establishing the endocochlear potential and sustaining production of endolymph. Abnormal cochlear microcirculation has long been considered an etiologic factor in noise-induced hearing loss, age-related hearing loss (presbycusis), sudden hearing loss or vestibular function, and Meniere's disease. Knowledge of the mechanisms underlying the pathophysiology of cochlear microcirculation is of fundamental clinical importance. A better understanding of cochlear blood flow (CoBF) will enable more effective management of hearing disorders resulting from aberrant blood flow. This review focuses on recent discoveries and findings related to the physiopathology of the cochlear microvasculature.
AB - Normal blood supply to the cochlea is critically important for establishing the endocochlear potential and sustaining production of endolymph. Abnormal cochlear microcirculation has long been considered an etiologic factor in noise-induced hearing loss, age-related hearing loss (presbycusis), sudden hearing loss or vestibular function, and Meniere's disease. Knowledge of the mechanisms underlying the pathophysiology of cochlear microcirculation is of fundamental clinical importance. A better understanding of cochlear blood flow (CoBF) will enable more effective management of hearing disorders resulting from aberrant blood flow. This review focuses on recent discoveries and findings related to the physiopathology of the cochlear microvasculature.
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U2 - 10.1016/j.heares.2011.08.006
DO - 10.1016/j.heares.2011.08.006
M3 - Review article
C2 - 21875658
AN - SCOPUS:82755160765
SN - 0378-5955
VL - 282
SP - 10
EP - 24
JO - Hearing Research
JF - Hearing Research
IS - 1-2
ER -