Pilot randomised trial of a healthy eating behavioural intervention in uncontrolled asthma

Jun Ma, Peg Strub, Nan Lv, Lan Xiao, Carlos A. Camargo, A. Sonia Buist, Philip W. Lavori, Sandra R. Wilson, Kari C. Nadeau, Lisa G. Rosas

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Rigorous research on the benefit of healthy eating patterns for asthma control is lacking. We randomised 90 adults with objectively confirmed uncontrolled asthma and a low-quality diet (Dietary Approaches to Stop Hypertension (DASH) scores <6 out of 9) to a 6-month DASH behavioural intervention (n=46) or usual-care control (n=44). Intention-to-treat analyses used repeated-measures mixed models. Participants were middle-aged, 67% female and multiethnic. Compared with controls, intervention participants improved on DASH scores (mean change (95% CI) 0.6 (0, 1.1) versus 0.3 (0.8, 0.2); difference 0.8 (0.2, 1.5)) and the primary outcome, Asthma Control Questionnaire scores (0.2 (0.5, 0) versus 0 (0.3, 0.3); difference 0.2 (0.5, 0.1)) at 6 months. The mean group differences in changes in Mini Asthma Quality of Life Questionnaire overall and subdomain scores consistently favoured the intervention over the control group: overall 0.4 (95% CI 0, 0.8), symptoms 0.5 (0, 0.9), environment 0.4 (0.1, 1.0), emotions 0.4 (0.2, 0.9) and activities 0.3 (0, 0.7). These differences were modest, but potentially clinical significant. The DASH behavioural intervention improved diet quality with promising clinical benefits for better asthma control and functional status among adults with uncontrolled asthma. A full-scale efficacy trial is warranted.

Original languageEnglish (US)
Pages (from-to)122-132
Number of pages11
JournalEuropean Respiratory Journal
Issue number1
StatePublished - Jan 1 2016

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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