TY - JOUR
T1 - Pilot randomised trial of a healthy eating behavioural intervention in uncontrolled asthma
AU - Ma, Jun
AU - Strub, Peg
AU - Lv, Nan
AU - Xiao, Lan
AU - Camargo, Carlos A.
AU - Buist, A. Sonia
AU - Lavori, Philip W.
AU - Wilson, Sandra R.
AU - Nadeau, Kari C.
AU - Rosas, Lisa G.
N1 - Funding Information:
This research was supported by grant R34 HL108753 from the National Heart, Lung and Blood Institute, and internal funding from the Palo Alto Medical Foundation Research Institute. P.W. Lavori acknowledges support by the Clinical and Translational Science Award 1UL1 RR025744 for the Stanford Centre for Clinical and Translational Education and Research (Spectrum) from the National Centre for Research Resources. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung and Blood Institute. No sponsor or funding source had a role in the design or conduct of the study; collection, management, analysis or interpretation of the data, or preparation, review or approval of the manuscript. Funding information for this article has been deposited with FundRef. We are indebted to the following individuals for their instrumental contributions to the conduct of the study: Veronica Luna, Andrea Blonstein, Elizabeth Jameiro and Nancy Wittels (Palo Alto Medical Foundation Research Institute, Palo Alto, CA, USA); Ranna Modir, Jennifer Waldrop and Jodi Thirtyacre (Kaiser Permanente of Northern California, San Francisco, CA, USA). We wish to thank the DASH Data and Safety Monitoring Board members, William Haskell, Ware G. Kuschner and Manisha Desai (Stanford University, Stanford, CA, USA), and extend special thanks to the DASH participants and their families who made this study possible. We also would like to acknowledge Unni C. Nygaard (Stanford University, Stanford, CA, USA) for her comments on the manuscript. The study was conducted while J. Ma was a faculty member at the Palo Alto Medical Foundation Research Institute.
Publisher Copyright:
© ERS 2016.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Rigorous research on the benefit of healthy eating patterns for asthma control is lacking. We randomised 90 adults with objectively confirmed uncontrolled asthma and a low-quality diet (Dietary Approaches to Stop Hypertension (DASH) scores <6 out of 9) to a 6-month DASH behavioural intervention (n=46) or usual-care control (n=44). Intention-to-treat analyses used repeated-measures mixed models. Participants were middle-aged, 67% female and multiethnic. Compared with controls, intervention participants improved on DASH scores (mean change (95% CI) 0.6 (0, 1.1) versus 0.3 (0.8, 0.2); difference 0.8 (0.2, 1.5)) and the primary outcome, Asthma Control Questionnaire scores (0.2 (0.5, 0) versus 0 (0.3, 0.3); difference 0.2 (0.5, 0.1)) at 6 months. The mean group differences in changes in Mini Asthma Quality of Life Questionnaire overall and subdomain scores consistently favoured the intervention over the control group: overall 0.4 (95% CI 0, 0.8), symptoms 0.5 (0, 0.9), environment 0.4 (0.1, 1.0), emotions 0.4 (0.2, 0.9) and activities 0.3 (0, 0.7). These differences were modest, but potentially clinical significant. The DASH behavioural intervention improved diet quality with promising clinical benefits for better asthma control and functional status among adults with uncontrolled asthma. A full-scale efficacy trial is warranted.
AB - Rigorous research on the benefit of healthy eating patterns for asthma control is lacking. We randomised 90 adults with objectively confirmed uncontrolled asthma and a low-quality diet (Dietary Approaches to Stop Hypertension (DASH) scores <6 out of 9) to a 6-month DASH behavioural intervention (n=46) or usual-care control (n=44). Intention-to-treat analyses used repeated-measures mixed models. Participants were middle-aged, 67% female and multiethnic. Compared with controls, intervention participants improved on DASH scores (mean change (95% CI) 0.6 (0, 1.1) versus 0.3 (0.8, 0.2); difference 0.8 (0.2, 1.5)) and the primary outcome, Asthma Control Questionnaire scores (0.2 (0.5, 0) versus 0 (0.3, 0.3); difference 0.2 (0.5, 0.1)) at 6 months. The mean group differences in changes in Mini Asthma Quality of Life Questionnaire overall and subdomain scores consistently favoured the intervention over the control group: overall 0.4 (95% CI 0, 0.8), symptoms 0.5 (0, 0.9), environment 0.4 (0.1, 1.0), emotions 0.4 (0.2, 0.9) and activities 0.3 (0, 0.7). These differences were modest, but potentially clinical significant. The DASH behavioural intervention improved diet quality with promising clinical benefits for better asthma control and functional status among adults with uncontrolled asthma. A full-scale efficacy trial is warranted.
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U2 - 10.1183/13993003.00591-2015
DO - 10.1183/13993003.00591-2015
M3 - Article
C2 - 26493792
AN - SCOPUS:84954205799
SN - 0903-1936
VL - 47
SP - 122
EP - 132
JO - European Respiratory Journal
JF - European Respiratory Journal
IS - 1
ER -