Pineal-adrenal interactions: The effect of acute pharmacological blockade of nocturnal melatonin secretion

Mark A. Demitrack; Alfred J. Lewy; Victor I. Reus

doi:10.1016/0165-1781(90)90085-J

Pineal-adrenal interactions: The effect of acute pharmacological blockade of nocturnal melatonin secretion

Mark A. Demitrack
, Alfred J. Lewy
, Victor I. Reus

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The pineal gland is a complex neuroendocrine organ which is under photoneuroendocrine control. Previous studies in animals and humans have suggested reciprocal variations in pineal melatonin biosynthesis and adrenal glucocorticoid output; it remains unclear, however, whether a causal relationship exists between these two systems. To address this question, we examined the overnight secretory activity of the hypothalamic-pituitary-adrenal (HPA) axis in conjunction with acute pharmacological suppression of pineal melatonin biosynthesis in 11 healthy volunteers. Results of the current study are consistent with the hypothesis that melatonin does not function as a tonic inhibitor of the HPA axis on an acute basis.

Original language	English (US)
Pages (from-to)	183-189
Number of pages	7
Journal	Psychiatry Research
Volume	32
Issue number	2
DOIs	https://doi.org/10.1016/0165-1781(90)90085-J
State	Published - Jan 1 1990
Externally published	Yes

Funding

Acknowledgments. The authors thank Dr. Sanford Markey of the National Institute of Mental Health for graciously supplying the deuterated 6hydroxymelatonin internal standard. The project was supported in part by BRSG Grant S07-RR05755( M.A.D.) awardedb y the Biomedical ResearchS upport Grant Program, Division of ResearchR esources,N ational Instituteso f Health.

Funders	Funder number
BRSG	S07-RR05755
Division of ResearchR esources
National Center for Research Resources	S07RR005755

Keywords

6-hydroxymelatonin
Pineal gland
cortisol
β-adrenergic receptor

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/0165-1781(90)90085-J

Cite this

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title = "Pineal-adrenal interactions: The effect of acute pharmacological blockade of nocturnal melatonin secretion",

abstract = "The pineal gland is a complex neuroendocrine organ which is under photoneuroendocrine control. Previous studies in animals and humans have suggested reciprocal variations in pineal melatonin biosynthesis and adrenal glucocorticoid output; it remains unclear, however, whether a causal relationship exists between these two systems. To address this question, we examined the overnight secretory activity of the hypothalamic-pituitary-adrenal (HPA) axis in conjunction with acute pharmacological suppression of pineal melatonin biosynthesis in 11 healthy volunteers. Results of the current study are consistent with the hypothesis that melatonin does not function as a tonic inhibitor of the HPA axis on an acute basis.",

keywords = "6-hydroxymelatonin, Pineal gland, cortisol, β-adrenergic receptor",

author = "Demitrack, \{Mark A.\} and Lewy, \{Alfred J.\} and Reus, \{Victor I.\}",

note = "Funding Information: Acknowledgments. The authors thank Dr. Sanford Markey of the National Institute of Mental Health for graciously supplying the deuterated 6hydroxymelatonin internal standard. The project was supported in part by BRSG Grant S07-RR05755( M.A.D.) awardedb y the Biomedical ResearchS upport Grant Program, Division of ResearchR esources,N ational Instituteso f Health.",

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doi = "10.1016/0165-1781(90)90085-J",

language = "English (US)",

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pages = "183--189",

journal = "Psychiatry Research",

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T2 - The effect of acute pharmacological blockade of nocturnal melatonin secretion

AU - Demitrack, Mark A.

AU - Lewy, Alfred J.

AU - Reus, Victor I.

N1 - Funding Information: Acknowledgments. The authors thank Dr. Sanford Markey of the National Institute of Mental Health for graciously supplying the deuterated 6hydroxymelatonin internal standard. The project was supported in part by BRSG Grant S07-RR05755( M.A.D.) awardedb y the Biomedical ResearchS upport Grant Program, Division of ResearchR esources,N ational Instituteso f Health.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The pineal gland is a complex neuroendocrine organ which is under photoneuroendocrine control. Previous studies in animals and humans have suggested reciprocal variations in pineal melatonin biosynthesis and adrenal glucocorticoid output; it remains unclear, however, whether a causal relationship exists between these two systems. To address this question, we examined the overnight secretory activity of the hypothalamic-pituitary-adrenal (HPA) axis in conjunction with acute pharmacological suppression of pineal melatonin biosynthesis in 11 healthy volunteers. Results of the current study are consistent with the hypothesis that melatonin does not function as a tonic inhibitor of the HPA axis on an acute basis.

AB - The pineal gland is a complex neuroendocrine organ which is under photoneuroendocrine control. Previous studies in animals and humans have suggested reciprocal variations in pineal melatonin biosynthesis and adrenal glucocorticoid output; it remains unclear, however, whether a causal relationship exists between these two systems. To address this question, we examined the overnight secretory activity of the hypothalamic-pituitary-adrenal (HPA) axis in conjunction with acute pharmacological suppression of pineal melatonin biosynthesis in 11 healthy volunteers. Results of the current study are consistent with the hypothesis that melatonin does not function as a tonic inhibitor of the HPA axis on an acute basis.

KW - 6-hydroxymelatonin

KW - Pineal gland

KW - cortisol

KW - β-adrenergic receptor

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SN - 0165-1781

VL - 32

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JO - Psychiatry Research

JF - Psychiatry Research

IS - 2

ER -

Pineal-adrenal interactions: The effect of acute pharmacological blockade of nocturnal melatonin secretion

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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