Place conditioning

Christopher L. Cunningham, Peter A. Groblewski, Charlene M. Voorhees

Research output: Chapter in Book/Report/Conference proceedingChapter

37 Scopus citations


Place conditioning is a form of stimulus-outcome learning that is commonly used to draw inferences about the rewarding and aversive effects of psychoactive drugs. This chapter focuses primarily on methodological issues that arise in the implementation and interpretation of place-conditioning studies. A description of the basic procedure is followed by a discussion of several key methodological issues, including compartment configuration, apparatus bias, stimulus selection, temporal parameters (interstimulus interval, trial duration, intertrial interval), experimental design and controls, dependent variables, and locomotor activity. Consideration is then given to methodological and interpretative issues that arise when using the place-conditioning procedure to study acquisition versus expression, extinction, and reinstatement of place conditioning. The chapter concludes with a brief discussion of the potential relevance of the place-conditioning procedure for understanding drug seeking and addiction in humans.

Original languageEnglish (US)
Title of host publicationAnimal Models of Drug Addiction
EditorsMary C. Olmstead
Number of pages23
StatePublished - 2011
Externally publishedYes

Publication series

ISSN (Print)0893-2336
ISSN (Electronic)1940-6045


  • Conditioned place aversion (CPA)
  • Conditioned place preference (CPP)
  • Conditioned reinforcement
  • Conditioning
  • Configural cues
  • Drug aversion
  • Drug reward
  • Drug seeking behavior
  • Extinction
  • Locomotion
  • Preference test
  • Reinstatement
  • Relapse
  • Stimulus selection
  • Unbiased procedure

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health


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