Placental growth factor: What hematologists need to know

Laura F. Newell; Shernan G. Holtan

doi:10.1016/j.blre.2016.08.004

Placental growth factor: What hematologists need to know

Laura F. Newell, Shernan G. Holtan

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

Although first identified in placenta, the angiogenic factor known as placental growth factor (PlGF) can be widely expressed in ischemic or damaged tissues. Recent studies have indicated that PlGF is a relevant factor in the pathobiology of blood diseases including hemoglobinopathies and hematologic malignancies. Therapies for such blood diseases may one day be based upon these and ongoing investigations into the role of PlGF in sickle cell disease, acute and chronic leukemias, and complications related to hematopoietic cell transplantation. In this review, we summarize recent studies regarding the potential role of PlGF in blood disorders and suggest avenues for future research.

Original language	English (US)
Pages (from-to)	57-62
Number of pages	6
Journal	Blood Reviews
Volume	31
Issue number	1
DOIs	https://doi.org/10.1016/j.blre.2016.08.004
State	Published - Jan 1 2017

Keywords

Graft-versus-host disease
Hematopoietic cell transplantation
Leukemia
Placental growth factor
Sickle cell anemia

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.blre.2016.08.004

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abstract = "Although first identified in placenta, the angiogenic factor known as placental growth factor (PlGF) can be widely expressed in ischemic or damaged tissues. Recent studies have indicated that PlGF is a relevant factor in the pathobiology of blood diseases including hemoglobinopathies and hematologic malignancies. Therapies for such blood diseases may one day be based upon these and ongoing investigations into the role of PlGF in sickle cell disease, acute and chronic leukemias, and complications related to hematopoietic cell transplantation. In this review, we summarize recent studies regarding the potential role of PlGF in blood disorders and suggest avenues for future research.",

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AU - Holtan, Shernan G.

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AB - Although first identified in placenta, the angiogenic factor known as placental growth factor (PlGF) can be widely expressed in ischemic or damaged tissues. Recent studies have indicated that PlGF is a relevant factor in the pathobiology of blood diseases including hemoglobinopathies and hematologic malignancies. Therapies for such blood diseases may one day be based upon these and ongoing investigations into the role of PlGF in sickle cell disease, acute and chronic leukemias, and complications related to hematopoietic cell transplantation. In this review, we summarize recent studies regarding the potential role of PlGF in blood disorders and suggest avenues for future research.

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Placental growth factor: What hematologists need to know

Abstract

Keywords

ASJC Scopus subject areas

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