Plasma lipids and hypertension: Response to calcium supplementation

N. Karanja, C. D. Morris, D. R. Illingworth, D. A. McCarron

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Evidence from animal and human studies indicate that calcium supplementation may ameliorate two risk factors for atherosclerotic cardiovascular disease, hypertension and hyperlipidemia. We sought to characterize dietary fat consumption and plasma lipid profiles in hypertensive and normotensive subjects and plasma lipid responses to supplemental calcium. A randomized, double-blind, placebo-controlled, crossover protocol was used to assess blood pressure and lipid response to 8 wk of 1000 mg of elemental calcium in 43 hypertensive and 27 normotensive subjects. Nutrient intakes and plasma lipids were measured repeatedly. Hypertensive female subjects consumed significantly less (p < 0.05) phosphorus, potassium, and magnesium and had significantly higher triglycerides (p < 0.04) and lower HDL-cholesterol (p < 0.02) than did normotensive subjects. There were no significant changes in dietary plasma lipids with calcium supplementation. Mildly hyperlipidemic normotensive subjects had a significant decrease in total cholesterol (p < 0.05). No significant changes in plasma occurred with calcium supplementation in hypertensive subjects.

Original languageEnglish (US)
Pages (from-to)60-65
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Issue number1
StatePublished - 1987

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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