TY - JOUR
T1 - Plasticity in the Aging Brain
T2 - Reversibility of Anatomic, Metabolic, and Cognitive Deficits in Normal-Pressure Hydrocephalus Following Shunt Surgery
AU - Kaye, Jeffrey A.
AU - Grady, Cheryl L.
AU - Haxby, James V.
AU - Moore, Angela
AU - Friedland, Robert P.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1990/12
Y1 - 1990/12
N2 - The course of idiopathic normal-pressure hydrocephalus was studied in a 78-year-old woman with a 4-year history of progressive dementia who underwent neuropsychologic testing, quantitative x-ray computed tomography, magnetic resonance imaging, and positron emission tomography with fludeoxyglucose F 18 to measure rates of regional cerebral glucose utilization. Preshunt cognitive testing demonstrated progressive deterioration during 2 years, and positron emission tomography showed significant reductions in regional cerebral glucose utilization of 34% to 49% as compared with age-and sex-matched control subjects in frontal, temporal, parietal, and whole brain regions. Periodic testing, carried out during a 2-year period after shunt surgery, showed steady improvement in clinical status. Parallel to the clinical changes, there was a significant reversal in neuropsychologic test scores with increased brain volume and increased regional cerebral glucose utilization in several brain regions. These results documented the considerable potential for recovery of compromised brain function in older subjects even after 4 years of progressive brain disease.
AB - The course of idiopathic normal-pressure hydrocephalus was studied in a 78-year-old woman with a 4-year history of progressive dementia who underwent neuropsychologic testing, quantitative x-ray computed tomography, magnetic resonance imaging, and positron emission tomography with fludeoxyglucose F 18 to measure rates of regional cerebral glucose utilization. Preshunt cognitive testing demonstrated progressive deterioration during 2 years, and positron emission tomography showed significant reductions in regional cerebral glucose utilization of 34% to 49% as compared with age-and sex-matched control subjects in frontal, temporal, parietal, and whole brain regions. Periodic testing, carried out during a 2-year period after shunt surgery, showed steady improvement in clinical status. Parallel to the clinical changes, there was a significant reversal in neuropsychologic test scores with increased brain volume and increased regional cerebral glucose utilization in several brain regions. These results documented the considerable potential for recovery of compromised brain function in older subjects even after 4 years of progressive brain disease.
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U2 - 10.1001/archneur.1990.00530120082014
DO - 10.1001/archneur.1990.00530120082014
M3 - Article
C2 - 2252451
AN - SCOPUS:0025608932
SN - 0003-9942
VL - 47
SP - 1336
EP - 1341
JO - Archives of Neurology
JF - Archives of Neurology
IS - 12
ER -