TY - JOUR
T1 - Platelet disorders
AU - Haley, Kristina M.
N1 - Funding Information:
Dr Haley has disclosed that she has received funding from the American Thrombosis and Hemostasis Network/Hemostasis Research Society to conduct research on women and girls with bleeding disorders. This commentary does not contain a discussion of unapproved/investigative use of a commercial product/device.
Funding Information:
disclosed that she has received funding from the American Thrombosis and Hemostasis Network/Hemostasis Research Society to conduct research on women and girls with bleeding disorders. This commentary does not contain a discussion of unapproved/ investigative use of a commercial product/ device.
Publisher Copyright:
Copyright © 2020 by the American Academy of Pediatrics. All rights reserved.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - After vascular injury and exposure of subendothelial matrix proteins to the intravascular space, mediators of hemostasis are triggered and allow for clot formation and restoration of vascular integrity. Platelets are the mediators of primary hemostasis, creating a platelet plug and allowing for initial cessation of bleeding. Platelet disorders, qualitative and quantitative, may result in bleeding signs and symptoms, particularly mucocutaneous bleeding such as epistaxis, bruising, petechiae, and heavy menstrual bleeding. Increasing evidence suggests that platelets have functional capabilities beyond hemostasis, but this review focuses solely on platelet hemostatic properties. Herein, normal platelet function as well as the effects of abnormal function and thrombocytopenia are reviewed.
AB - After vascular injury and exposure of subendothelial matrix proteins to the intravascular space, mediators of hemostasis are triggered and allow for clot formation and restoration of vascular integrity. Platelets are the mediators of primary hemostasis, creating a platelet plug and allowing for initial cessation of bleeding. Platelet disorders, qualitative and quantitative, may result in bleeding signs and symptoms, particularly mucocutaneous bleeding such as epistaxis, bruising, petechiae, and heavy menstrual bleeding. Increasing evidence suggests that platelets have functional capabilities beyond hemostasis, but this review focuses solely on platelet hemostatic properties. Herein, normal platelet function as well as the effects of abnormal function and thrombocytopenia are reviewed.
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U2 - 10.1542/pir.2018-0359
DO - 10.1542/pir.2018-0359
M3 - Article
C2 - 32358028
AN - SCOPUS:85084894742
SN - 0191-9601
VL - 41
SP - 224
EP - 234
JO - Pediatrics in Review
JF - Pediatrics in Review
IS - 5
ER -