@article{beb7a33342b84b19ac3a4735cb2b8099,
title = "Platelet response to acute blood loss: An experimental study",
abstract = "The platelet changes associated with acute blood loss were studied in dogs and baboons. The circulating platelets decreased and aggregability increased in response to hemorrhage. Intrinsic ATP and ADP concentrations and ultrastructural morphology did not change significantly. These results explain, in part, the coagulopathy that occurs in the trauma victim in hemorrhagic shock. Based upon these observations, the authors describe a resuscitative program that includes whole blood and platelet administration.",
keywords = "blood, clotting, blood, platelet, shock, hemorrhagic, shock, hypovolemic",
author = "Lim, {Robert C.} and Holcroft, {James W.} and Trunkey, {Donald D.}",
note = "Funding Information: The pathophysiology of hemor rhagic shock secondary to sudden acute blood loss must be elucidated to provide a deeper insight into its management in the emergency department. With improvement of prehospital care, more patients in hemorrhagic shock are reaching the emergency department alive. Aggressive resuscitation has increased the survival rate of these patients but now we are faced with a new challenge--complications of resuscitation. Shock lung has been well described but the * Department of Sm'gery and Trauma C enter, University of California, San Francisco General Hospital, San Francisco, California 94110. Supported by National Institutes of Health GM #18470. Presented at the Fifth Annual Meeting of UA/EMS in Vancouver, British Columbia, Canada, May 1975.",
year = "1975",
doi = "10.1016/S0361-1124(75)80032-3",
language = "English (US)",
volume = "4",
pages = "524--527",
journal = "Journal of the American College of Emergency Physicians",
issn = "0361-1124",
publisher = "Mosby Inc.",
number = "6",
}