Pleiotropic signaling pathways in rapid, nongenomic action of glucocorticoid

Yi Zhang Chen; Jian Qiu

doi:10.1006/mcbr.1999.0163

Pleiotropic signaling pathways in rapid, nongenomic action of glucocorticoid

Yi Zhang Chen, Jian Qiu

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

The traditional genomic theory of steroid action does not fully explain the rapid effects of hormonal steroids, and it is thought that the nongenomic actions mediated by a putative membrane receptor may provide a plausible explanation. Although there is a rich body of evidence to substantiate the rapid, nongenomic effects of steroid hormones, the signal transduction pathways involved have proved to be complex and pleiotropic. Based on previous studies on the rapid, nongenomic actions of glucocorticoid (GC) and the G-protein-protein kinase pathways involved, including our own studies on PC12, SK-N-SH, BT-325 cells, and synaptosomes, in this review we will discuss the issue of multiple signal transduction pathways involved in the rapid, nongenomic effects of GC.

Original language	English (US)
Pages (from-to)	145-149
Number of pages	5
Journal	Molecular Cell Biology Research Communications
Volume	2
Issue number	3
DOIs	https://doi.org/10.1006/mcbr.1999.0163
State	Published - Sep 1999
Externally published	Yes

Keywords

Cells
Glucocorticoid
Nongenomic
Pleotropic
Receptor
Signal transduction

ASJC Scopus subject areas

Molecular Biology

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10.1006/mcbr.1999.0163

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title = "Pleiotropic signaling pathways in rapid, nongenomic action of glucocorticoid",

abstract = "The traditional genomic theory of steroid action does not fully explain the rapid effects of hormonal steroids, and it is thought that the nongenomic actions mediated by a putative membrane receptor may provide a plausible explanation. Although there is a rich body of evidence to substantiate the rapid, nongenomic effects of steroid hormones, the signal transduction pathways involved have proved to be complex and pleiotropic. Based on previous studies on the rapid, nongenomic actions of glucocorticoid (GC) and the G-protein-protein kinase pathways involved, including our own studies on PC12, SK-N-SH, BT-325 cells, and synaptosomes, in this review we will discuss the issue of multiple signal transduction pathways involved in the rapid, nongenomic effects of GC.",

keywords = "Cells, Glucocorticoid, Nongenomic, Pleotropic, Receptor, Signal transduction",

author = "Chen, {Yi Zhang} and Jian Qiu",

note = "Funding Information: 1This work was supported by research grants from the Natural Science Foundation of China (NFSC) Grant No. 39330100, 39840019. 2To whom correspondence and reprint requests should be addressed. Fax: (86) (21)65343087. E-mail: yzchen@public.sta.net.cn.",

year = "1999",

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doi = "10.1006/mcbr.1999.0163",

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AU - Chen, Yi Zhang

AU - Qiu, Jian

N1 - Funding Information: 1This work was supported by research grants from the Natural Science Foundation of China (NFSC) Grant No. 39330100, 39840019. 2To whom correspondence and reprint requests should be addressed. Fax: (86) (21)65343087. E-mail: yzchen@public.sta.net.cn.

PY - 1999/9

Y1 - 1999/9

N2 - The traditional genomic theory of steroid action does not fully explain the rapid effects of hormonal steroids, and it is thought that the nongenomic actions mediated by a putative membrane receptor may provide a plausible explanation. Although there is a rich body of evidence to substantiate the rapid, nongenomic effects of steroid hormones, the signal transduction pathways involved have proved to be complex and pleiotropic. Based on previous studies on the rapid, nongenomic actions of glucocorticoid (GC) and the G-protein-protein kinase pathways involved, including our own studies on PC12, SK-N-SH, BT-325 cells, and synaptosomes, in this review we will discuss the issue of multiple signal transduction pathways involved in the rapid, nongenomic effects of GC.

AB - The traditional genomic theory of steroid action does not fully explain the rapid effects of hormonal steroids, and it is thought that the nongenomic actions mediated by a putative membrane receptor may provide a plausible explanation. Although there is a rich body of evidence to substantiate the rapid, nongenomic effects of steroid hormones, the signal transduction pathways involved have proved to be complex and pleiotropic. Based on previous studies on the rapid, nongenomic actions of glucocorticoid (GC) and the G-protein-protein kinase pathways involved, including our own studies on PC12, SK-N-SH, BT-325 cells, and synaptosomes, in this review we will discuss the issue of multiple signal transduction pathways involved in the rapid, nongenomic effects of GC.

KW - Cells

KW - Glucocorticoid

KW - Nongenomic

KW - Pleotropic

KW - Receptor

KW - Signal transduction

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Pleiotropic signaling pathways in rapid, nongenomic action of glucocorticoid

Abstract

Keywords

ASJC Scopus subject areas

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